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Autor:
Clarence E Locklear, Zachary T Glovak, Helen A. Baghdoyan, Christopher B O'Brien, Ralph Lydic, Diana Zebadua Unzaga
Publikováno v:
Journal of Neurophysiology. 126:1265-1275
The electroencephalogram (EEG) provides an objective, neural correlate of consciousness. Opioid receptors modulate mammalian neuronal excitability, and this fact was used to characterize how opioids administered to mice alter EEG power and states of
Autor:
Daniel W. Shi, Yu Fu, Yanbo Tang, Xuan Zheng Shi, Shrilakshmi Hegde, Li Yen Mae Huang, You-Min Lin
Publikováno v:
Am J Physiol Gastrointest Liver Physiol
Constipation and abdominal pain are commonly encountered in opioid-induced bowel dysfunction (OBD). The underlying mechanisms are incompletely understood, and treatments are not satisfactory. As patients with OBD often have fecal retention, we aimed
Autor:
Thomas M. Coffman, Donna L. Ralph, Rishav Adhikari, Alicia A. McDonough, Emre Dilmen, Alison N. Hollis, Susan B. Gurley, Thien A. Hoang, Fitra Rianto, Gabriel Chew, Enrico Petretto, Matthew A. Sparks, Edward J. Diaz
Publikováno v:
American Journal of Physiology : Renal Physiology, 320, F1080-F1092
American Journal of Physiology : Renal Physiology, 320, 6, pp. F1080-F1092
Am J Physiol Renal Physiol
American Journal of Physiology : Renal Physiology, 320, 6, pp. F1080-F1092
Am J Physiol Renal Physiol
Contains fulltext : 238842.pdf (Publisher’s version ) (Closed access) A major pathway in hypertension pathogenesis involves direct activation of ANG II type 1 (AT(1)) receptors in the kidney, stimulating Na(+) reabsorption. AT(1) receptors in tubul
Autor:
Evgenia Dobrinskikh, Brittany Butler, Clyde J. Wright, David J. Orlicky, Thom Sizemore, Lijun Zheng, Robyn De Dios, Laura G Sherlock, Durga Balasubramaniyan
Publikováno v:
Am J Physiol Lung Cell Mol Physiol
Acetaminophen ( n-acetyl-p-aminophenol, APAP) use in the neonatal intensive care unit is rapidly increasing. Although APAP-related hepatotoxicity is rarely reported in the neonatal literature, other end-organ toxicity can occur with toxic exposures.
Publikováno v:
American Journal of Physiology-Renal Physiology. 320:F963-F971
Psychotropic drugs may be associated with hyponatremia, but an understanding of how they induce water retention in the kidney remains elusive. Previous studies have postulated that they may increase vasopressin production in the hypothalamus without
Autor:
Nicholas D. Fried, Jason D. Gardner, Tamara M. Morris, Eric Lazartigues, Xinping Yue, Anna Whitehead
Publikováno v:
Am J Physiol Heart Circ Physiol
Use of electronic cigarettes is rapidly increasing among youth and young adults, but little is known regarding the long-term cardiopulmonary health impacts of these nicotine-containing devices. Our group has previously demonstrated that chronic, inha
Publikováno v:
Journal of Neurophysiology. 125:1202-1212
Cisplatin is an antitumor drug that is widely used for the treatment of various solid tumors. Unfortunately, patients are often troubled by serious side effects, especially hearing loss. Up to now, there have been no clear and effective measures to p
Autor:
Asmaa Mohammed ShamsEldeen, Abhay Srivastava, Samaa S Kamar, Sanjiv Dhingra, Heba Samy Shoukry, Hend Ashour, Hania Ibrahim Ammar, Laila A. Rashed, Mostafa S. Fadel
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 320:H1290-H1302
Bone marrow-derived mesenchymal stem cells (BM-MSCs) have demonstrated potential in treating diabetic cardiomyopathy. However, patients with diabetes are on multiple drugs and there is a lack of understanding of how transplanted stem cells would resp
Publikováno v:
Viisanen, H, Lilius, T O, Sagalajev, B, Rauhala, P, Kalso, E & Pertovaara, A 2020, ' Neurophysiological response properties of medullary pain-control neurons following chronic treatment with morphine or oxycodone : Modulation by acute ketamine ', Journal of Neurophysiology, vol. 124, no. 3, pp. 790-801 . https://doi.org/10.1152/jn.00343.2020
Descending facilitatory circuitry that involves the rostroventromedial medulla (RVM) exerts a significant role in the development of antinociceptive tolerance and hyperalgesia following chronic morphine treatment. The role of the RVM in the developme
Autor:
Jasneet Parmar, James Howells, Daniel White, David Goldstein, Susanna B. Park, Justin G. Lees, Preet G.S. Makker, Gila Moalem-Taylor
Publikováno v:
Journal of Neurophysiology. 124:232-244
Oxaliplatin chemotherapy produces acute changes in peripheral nerve excitability in humans by modulating voltage-gated Na+ channel activity. However, there are few animal studies of oxaliplatin-induced neuropathy that demonstrate similar changes in e