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Autor:
Jeff Reese, Robert B. Cotton, Jeremy A. Goettel, James L. Wynn, Bibhash C. Paria, Megan Vucovich, Stanley D. Poole, Reese H. Clark, Elaine L. Shelton, Mario A. Rojas, Noah J. Ehinger, Naoko Brown, James C. Slaughter
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 307:H732-H740
Sepsis is strongly associated with patency of the ductus arteriosus (PDA) in critically ill newborns. Inflammation and the aminoglycoside antibiotics used to treat neonatal sepsis cause smooth muscle relaxation, but their contribution to PDA is unkno
Autor:
Dirk J. Duncker, Daphne Merkus, Maaike Hoekstra, Vincent J. de Beer, Veemal Hemradj, Zhichao Zhou, Fen Gao
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology, 302(8), H1747-H1755. American Physiological Society
Zhou Z, Hemradj V, de Beer VJ, Gao F, Hoekstra M, Merkus D, Duncker DJ. Cytochrome P-450 2C9 exerts a vasoconstrictor influence on coronary resistance vessels in swine at rest and during exercise. Am J Physiol Heart Circ Physiol 302: H1747-H1755, 201
Publikováno v:
American Journal of Physiology-Renal Physiology. 291:F619-F628
Endothelial dysfunction in ischemic acute renal failure (IARF) has been attributed to both direct endothelial injury and to altered endothelial nitric oxide synthase (eNOS) activity, with either maximal upregulation of eNOS or inhibition of eNOS by e
Publikováno v:
American Journal of Physiology-Renal Physiology. 289:F137-F144
Raloxifene may confer vascular benefits without causing estrogen-related side effects. However, its action on renal vascular circulation is unknown. This study aimed to examine the sex difference and roles of the endothelium and Ca2+ channels in rat
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 288:H1411-H1416
The vascular response to adenosine and its analogs is mediated by four adenosine receptors (ARs), namely, A1, A2A, A2B, and A3. A2AARs and/or A2BARs are involved in adenosine-mediated vascular relaxation of coronary and aortic beds. However, the role
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 287:H1064-H1071
Using superior mesenteric artery rings isolated from age-matched controls and streptozotocin (STZ)-induced diabetic rats, we recently demonstrated that EDHF-type relaxation is impaired in STZ-induced diabetic rats, possibly due to a reduced action of
Publikováno v:
Journal of Applied Physiology. 96:1105-1113
We tested the hypothesis that exercise training (Ex) attenuates the effects of hypercholesterolemia on endothelium-dependent relaxation in left anterior descending coronary arteries. Adult female pigs were fed a normal-fat (NF) or high-fat (HF) diet
Autor:
Yasuaki Yashiro, Brian R. Duling
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 285:H65-H73
We examined the role played by intracellular Ca2+stores in conducted vasomotor responses induced by phenylephrine (PE) in isolated hamster cremasteric arterioles. When applied briefly (∼1 s) to isolated, cannulated arterioles by using pressure-puls
Autor:
Atsushi Sato, Takashi Saito, Ossama A. Hatoum, Sara A. Manthei, John J. Bosnjak, Hiroto Miura, Ken Terata, Alfred C. Nicolosi, Monica McDonald, David D. Gutterman
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 284:H1080-H1086
Thrombin (Thromb), activated as part of the clotting cascade, dilates conduit arteries through an endothelial pertussis toxin (PTX)-sensitive G-protein receptor and releases nitric oxide (NO). Thromb also acts on downstream microvessels. Therefore, w
Publikováno v:
Journal of Applied Physiology. 92:2035-2044
We hypothesized that estradiol treatment would improve vascular dysfunction commonly associated with obesity, hyperlipidemia, and insulin resistance. A sham operation or 17β-estradiol pellet implantation was performed in male lean and obese Zucker r