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Autor:
Dennis K Fix, Patrick J Ferrara, Micah J. Drummond, Alec I. McKenzie, Jonathan J Petrocelli, Katsuhiko Funai, Paul T Reidy, Ziad S. Mahmassani, Naomi M de Hart
Publikováno v:
Am J Physiol Cell Physiol
Muscle progenitor cells (MPCs) in aged muscle exhibit impaired activation into proliferating myoblasts, thereby impairing fusion and changes in secreted factors. The antihyperglycemic drug metformin, currently studied as a candidate antiaging therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7212ce576f6a0dcf98bd32684353fc4
https://europepmc.org/articles/PMC8424538/
https://europepmc.org/articles/PMC8424538/
Autor:
John David Ganther, Alaa Khatib, Omar Tliba, Blerina Kokalari, Danielle O'Connell, Belaid Bouazza, Yassine Amrani
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 309:L348-L359
Although the majority of patients with asthma are well controlled by inhaled glucocorticoids (GCs), patients with severe asthma are poorly responsive to GCs. This latter group is responsible for a disproportionate share of health care costs associate
Publikováno v:
American Journal of Physiology-Renal Physiology. 303:F1300-F1306
Pharmacological blockade of cyclic nucleotide phosphodiesterase (PDE) can relax human urinary bladder smooth muscle (UBSM); however, the underlying cellular mechanism is unknown. In this study, we investigated the effects of PDE pharmacological block
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 303:H784-H794
The mechanisms by which NaCl raises blood pressure (BP) in hypertension are unresolved, but much evidence indicates that endogenous ouabain is involved. In rodents, arterial smooth muscle cell (ASMC) Na+pumps with an α2-catalytic subunit (ouabain EC
Autor:
Philippe Devillier, Benoit Douvry, Priscilla Henno, Marilyne Lévy, Jean-François Boitiaux, Christophe Delclaux, Aurélie Cazes, Dominique Israel-Biet
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 300:L831-L839
Pulmonary vascular remodeling and dysfunction associated to tobacco smoking might pave the way for the subsequent development of pulmonary hypertension. Its prognosis is dreadful and its underlying mechanisms are so far largely unknown in humans. To
Autor:
Peter Grafe, Dominik Irnich, Ralf Burgstahler, Beate Schlotter-Weigel, Philip M. Lang, Wolfgang Sippel
Publikováno v:
Journal of Neurophysiology. 90:3295-3303
Application of acetylcholine to peripheral nerve terminals in the skin is a widely used test in studies of human small-fiber functions. However, a detailed pharmacological profile and the subunit composition of nicotinic acetylcholine receptors in hu
Autor:
Brian G. Kennedy, G. F. Jin, Tianxiang Weng, Nancy J. Mangini, N. K. Wills, Alan S.L. Yu, B. F. Godley
Publikováno v:
American Journal of Physiology-Cell Physiology. 283:C839-C849
Retinal pigment epithelium (RPE) possesses regulated chloride channels that are crucial for transepithelial fluid and ion transport. At present, little is known about the molecular nature of chloride channels in human adult RPE (haRPE) or the effects
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 280:L79-L87
Submucosal glands were isolated within 4 h of death from tracheae and bronchi obtained from autopsied lungs, and the secretory response of secretory leukocyte protease inhibitor (SLPI) was examined with ELISA and a secretory index. Although human neu
Autor:
Mutsuo Yamaya, Tomoko Suzuki, Norihiro Yamada, Katsutoshi Nakayama, Masahito Kamanaka, Yoshio Numazaki, Kiyohisa Sekizawa, Satoshi Ishizuka, Tetsushi Morimoto, Hidetada Sasaki
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 278:L560-L571
To examine the effects of glucocorticoid on rhinovirus (RV) infection, primary cultures of human tracheal epithelial cells were infected with either RV2 or RV14. Viral infection was confirmed by demonstrating that viral RNA in infected cells and vira
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 277:L22-L29
In a variety of diseases, inflammation causes microvascular leakage and activates thrombin. Evidence suggests that thrombin increases cytosolic calcium and stimulates human airway smooth muscle (ASM) cell proliferation. The receptor subtypes, however