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Autor:
Maria E. Teves, Eduardo R. S. Roldan
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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The spermatozoon is a highly differentiated and polarized cell, with two main structures: the head, containing a haploid nucleus and the acrosomal exocytotic granule, and the flagellum, which generates energy and propels the cell; both structures are
Publikováno v:
Physiol Rev
Cells metabolize nutrients for biosynthetic and bioenergetic needs to fuel growth and proliferation. The uptake of nutrients from the environment and their intracellular metabolism is a highly controlled process that involves cross talk between growt
Publikováno v:
Physiological Reviews. 101:683-731
Several diseases and conditions have been associated with an uncontrolled rise in bile acid (BA) concentrations. This is often the case when the tight feedback regulation of BA synthesis is compromised to the point that BAs become detrimental. BAs an
Autor:
Edward T.H. Yeh, Hui-Ming Chang
Publikováno v:
Physiol Rev
Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates multiple biological processes, including cell division, DNA replication/repair, signal transduction, and cellular metabolism. In this review, we will focus on
Publikováno v:
Physiological Reviews. 99:1655-1699
Integrins are heterodimeric cell surface receptors ensuring the mechanical connection between cells and the extracellular matrix. In addition to the anchorage of cells to the extracellular matrix, these receptors have critical functions in intracellu
Autor:
Ole H. Petersen, Julia Vladimirovna Gerasimenko, Oleksiy Gryshchenko, Shuang Peng, Oleg Vsevolodovich Gerasimenko
This review deals with the roles of calcium and ATP in the control of the normal functions of the different cell types in the exocrine pancreas as well as the roles of these molecules in the pathophysiology of Acute Pancreatitis. Repetitive rises in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b021470b15a7f3fb99e38576c40a46af
https://orca.cardiff.ac.uk/id/eprint/141137/7/physrev.00003.2021.pdf
https://orca.cardiff.ac.uk/id/eprint/141137/7/physrev.00003.2021.pdf
Publikováno v:
Physiological Reviews. 99:1249-1279
Nuclear receptors are intracellular proteins that act as transcription factors. Proteins with classic nuclear receptor domain structure lacking identified signaling ligands are designated orphan nuclear receptors. Two of these, steroidogenic factor-1
Autor:
Jeffrey L. Garvin, Fara Saez, Jessica Asirwatham, Agustin Gonzalez-Vicente, Casandra Margarita Monzón
Publikováno v:
Physiological Reviews. 99:235-309
The thick ascending limb plays a key role in maintaining water and electrolyte balance. The importance of this segment in regulating blood pressure is evidenced by the effect of loop diuretics or local genetic defects on this parameter. Hormones and
Autor:
Gerald W. Dorn, Åsa B. Gustafsson
Publikováno v:
Physiological Reviews. 99:853-892
The central functions fulfilled by mitochondria as both energy generators essential for tissue homeostasis and gateways to programmed apoptotic and necrotic cell death mandate tight control over the quality and quantity of these ubiquitous endosymbio
Publikováno v:
Physiological Reviews. 99:707-738
The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to the ATP binding cassette (ABC) transporter superfamily but functions as an anion channel crucial for salt and water transport across epithelial cells. CFTR dysfunction, because