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of 253
pro vyhledávání: ''
Autor:
Stephen J. Greene, Muthiah Vaduganathan, Brian Claggett, Ankeet S. Bhatt, Rahul Aggarwal, Gregg C. Fonarow, Scott D. Solomon, John J.V. McMurray
Publikováno v:
JAMA Cardiology. 6:1415
Importance The US Food and Drug Administration (FDA) expanded labeling for sacubitril/valsartan for use in individuals with chronic heart failure (HF) with left ventricular ejection fraction (LVEF) lower than normal. The population-level implications
Autor:
Mary P Cosimano, Darrick G. May, Nathan D. Sepeda, Roland R. Griffiths, Frederick S. Barrett, Alan K. Davis, Matthew W. Johnson, Patrick H. Finan
Publikováno v:
JAMA Psychiatry
This randomized clinical trial examines the efficacy of psilocybin as an adjunct to psychotherapy and other treatments for major depressive disorder.
Key Points Question Is psilocybin-assisted therapy efficacious among patients with major depres
Key Points Question Is psilocybin-assisted therapy efficacious among patients with major depres
Autor:
Eduardo López-Medina, Pio Lopez, Maria Cristina Lesmes, Ana C. Avendaño, Ernesto Martínez, Hector Chavarriaga, Sócrates Herrera, Jose Oñate, Diana M. Dávalos, Isabella Caicedo, Gerardo Libreros, Dilian Francisca Toro, Jesus A. Díazgranados, Carlos A. Rios, Miyerlandi Torres, Roberto Jaramillo, Beatriz Parra, Oscar Ramirez, Isabel Cristina Hurtado
Publikováno v:
JAMA
Importance Ivermectin is widely prescribed as a potential treatment for COVID-19 despite uncertainty about its clinical benefit. Objective To determine whether ivermectin is an efficacious treatment for mild COVID-19. Design, Setting, and Participant
Autor:
Cielo Bingley, Deep Grewal, Stuart A. McCluskey, Vivek Rao, Justyna Bartoszko, Keyvan Karkouti, Jo Carroll, Chantal Armali, Jeannie Callum, Amie Kron, Hans-Peter Hucke
Publikováno v:
JAMA Network Open
Key Points Question Can 4-factor prothrombin complex concentrate (PCC) be used as a substitute for frozen plasma (FP) for treatment of bleeding related to coagulation factor deficiency in cardiac surgery? Findings In this pilot trial, 101 adult patie
Autor:
Pavlos Msaouel, Joseph Lubega, Eyal Muscal, Timothy Lotze, Lisa R. Forbes, Martha Barrow, Kristen Curry, Carl E. Allen, Poyyapakkam Srivaths, Casey L. McAtee, Kristen Underbrink, M. Brooke Bernhardt
Publikováno v:
JAMA Network Open
Key Points Question Is the use of rituximab for young people associated with short- or long-term adverse events? Findings This cohort study identified 468 patients younger than 21 years receiving rituximab for more than 25 indications, among whom inf
Publikováno v:
JAMA Ophthalmol
IMPORTANCE: Pigment epithelial detachment (PED) is a feature commonly associated with neovascular age-related macular degeneration (nAMD) and may be perceived as being difficult to treat. Therefore, this investigation explored changes in PEDs and vis
Autor:
Miroslav Veith, Neil M. Bressler, Vogt Gabor, Veronika Matušková, Jan Ernest, András Papp, Tamás Pregun, Donghoon Shin, Jan Hamouz, Attila Vajas, Jan Studnička, Dominik Zalewski, James Luu, Young Hee Yoon, Se Joon Woo, Taehyung Kim
Publikováno v:
JAMA Ophthalmol
Importance Neovascular age-related macular degeneration is the leading cause of blindness in individuals 50 years or older. The availability of a ranibizumab biosimilar product (SB11) may facilitate access to an effective alternative to this treatmen
Autor:
Eric D. Achtyes, Robert D. Gibbons, Nina R. Schooler, John M. Kane, Christoph U. Correll, Patricia Marcy, Delbert G. Robinson
Publikováno v:
JAMA Psychiatry
Importance Long-acting injectable antipsychotics (LAIs) can potentially reduce hospitalization risk by enhancing medication adherence but are rarely considered for early-phase schizophrenia treatment. Objective To determine whether encouraging use of
Autor:
Jason S. Ehrlich, Aaron Osborne, Sunil S. Patel, Susanna Grzeschik, Philip J. Ferrone, Arshad M. Khanani, Zdenka Haskova, Karen Basu, Jayashree Sahni, Pravin U. Dugel
Publikováno v:
JAMA Ophthalmol
Importance Faricimab neutralizes angiopoietin-2 and vascular endothelial growth factor A via both simultaneous and independent binding. Objective To evaluate extended dosing with faricimab, the first bispecific antibody designed for intraocular use,
Autor:
Jehill D Parikh, Avais Jabbar, Peter Carey, Deborah Stocken, David Austin, Kieren G. Hollingsworth, Lorna Ingoe, Azfar Zaman, Simon H. S. Pearce, Salman Razvi, Honey Thomas, John P Greenwood, Shahid Junejo, Caroline Addison
Publikováno v:
JAMA. 324:249
Importance Thyroid hormones play a key role in modulating myocardial contractility. Subclinical hypothyroidism in patients with acute myocardial infarction is associated with poor prognosis. Objective To evaluate the effect of levothyroxine treatment