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Publikováno v:
JAMA Network Open
Key Points Question Is peer influence associated with physician adoption of new cancer therapies? Findings In this cohort study of 44 012 Medicare beneficiaries with cancer treated by 3261 oncologists, use of bevacizumab in 2007 to 2010 was greater a
Autor:
Michael J. Englesbe, Sunil Agarwal, Jay S. Lee, Chad M. Brummett, Kao-Ping Chua, Jennifer F. Waljee, Hsou Mei Hu, John D. Bryan, Rebecca L. Haffajee
Publikováno v:
JAMA Network Open
Key Points Question What is the association of opioid prescribing duration limits with postoperative opioid prescribing in Massachusetts and Connecticut? Findings This interrupted time series analysis and cross-sectional study of 16 281 opioid-naive
Publikováno v:
JAMA Network Open
Aspirin use has been associated with reduced risk of cancer mortality, particularly of the colorectum. However, aspirin efficacy may be influenced by biological characteristics, such as obesity and age. With the increasing prevalence of obesity and c
Autor:
Colleen M. Brensinger, Craig Newcomb, Hannah Wunsch, Mark D. Neuman, Duminda N. Wijeysundera, Karim S. Ladha, Tobias Svensson, Max Bell, Lakisha J. Gaskins, Brian T. Bateman, Gabriella Bröms, Jennifer Bethell, Linn Hallqvist
Publikováno v:
JAMA Network Open. 2:e1910734
Small studies and anecdotal evidence suggest marked differences in the use of opioids after surgery internationally; however, this has not been evaluated systematically across populations receiving similar procedures in different countries.To determi
Autor:
Clayton H. Brown, Michael L. Terrin, Laurence S. Magder, Kristen A Stafford, Jon Mark Hirshon, Aldo Iacono, Marniker Wijesinha
Publikováno v:
JAMA Network Open
Key Points Question Which immunosuppressive strategy is associated with the highest survival in lung transplantation? Findings In this cohort study of US recipients of lung transplants, sirolimus plus tacrolimus was associated with significantly bett
Autor:
Boang Liu, Shirley Cohen-Mekelburg, Ryan W. Stidham, Akbar K. Waljee, Ji Zhu, Peter D.R. Higgins, Beth I Wallace, Kay Sauder, Yumu Liu
Publikováno v:
JAMA Network Open
Key Points Question Can laboratory data be used to predict durable response to ustekinumab among patients with Crohn disease before they commit to long-term treatment? Findings In this cohort study of 401 participants with active Crohn disease, a pre
Autor:
Robert C. Smallridge, Ana Maria Chindris, Electron Kebebew, Athanasios Bikas, Brianna Daley, Leonard Wartofsky, Kenneth D. Burman, Eliza Dewey, Sungyoung Auh, Joanna Klubo-Gwiezdzinska, Marvin C. Gershengorn, Mark L. Urken
Publikováno v:
JAMA Network Open
Key Points Question Is thyrotropin suppression associated with better outcomes in patients with intermediate- and high-risk differentiated thyroid cancer? Findings In this cohort study including 867 patients with intermediate- and high-risk different
Autor:
Benjamin Djulbegovic, Rahul Mhaskar
Publikováno v:
JAMA. 320:1483
Clinical Question Among patients with multiple myeloma, is bisphosphonate therapy associated with lower rates of mortality, vertebral fractures, nonvertebral fractures, and skeletal-related events compared with placebo or no treatment? Bottom Line Am
Autor:
Andrea M. Austin, Gabriel A. Brooks, Anna N. A. Tosteson, Deborah Schrag, Hajime Uno, Konstantin H. Dragnev
Publikováno v:
JAMA Network Open
Key Points Question Does the risk of hospitalization among elderly patients receiving chemotherapy for metastatic, nonsquamous, non–small cell lung cancer vary by chemotherapy regimen? Findings In a cohort study of 2182 propensity-matched Medicare
Autor:
Markku Aarnio, Juhani Sand, Tero Rautio, Tuomo Rantanen, Risto Tuominen, Hannu Paajanen, Jukka-Pekka Mecklin, Paulina Salminen, Saija Hurme, Juha Grönroos, Johanna Virtanen, Airi Jartti, Pia Nordström
Publikováno v:
JAMA. 320:1259
Short-term results support antibiotics as an alternative to surgery for treating uncomplicated acute appendicitis, but long-term outcomes are not known.To determine the late recurrence rate of appendicitis after antibiotic therapy for the treatment o