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Publikováno v:
JAMA Network Open
Key Points Question Is peer influence associated with physician adoption of new cancer therapies? Findings In this cohort study of 44 012 Medicare beneficiaries with cancer treated by 3261 oncologists, use of bevacizumab in 2007 to 2010 was greater a
Autor:
Robert C. Smallridge, Ana Maria Chindris, Electron Kebebew, Athanasios Bikas, Brianna Daley, Leonard Wartofsky, Kenneth D. Burman, Eliza Dewey, Sungyoung Auh, Joanna Klubo-Gwiezdzinska, Marvin C. Gershengorn, Mark L. Urken
Publikováno v:
JAMA Network Open
Key Points Question Is thyrotropin suppression associated with better outcomes in patients with intermediate- and high-risk differentiated thyroid cancer? Findings In this cohort study including 867 patients with intermediate- and high-risk different
Autor:
Andrea M. Austin, Gabriel A. Brooks, Anna N. A. Tosteson, Deborah Schrag, Hajime Uno, Konstantin H. Dragnev
Publikováno v:
JAMA Network Open
Key Points Question Does the risk of hospitalization among elderly patients receiving chemotherapy for metastatic, nonsquamous, non–small cell lung cancer vary by chemotherapy regimen? Findings In a cohort study of 2182 propensity-matched Medicare
Publikováno v:
JAMA Network Open. 1:e180416
Importance Based on efficacy results from pivotal randomized clinical trials, PD-1 (programmed cell death 1) inhibitors, such as nivolumab and pembrolizumab, have been approved to treat various cancers. Response patterns with varying effects on progr
Publikováno v:
JAMA. 317:1835
The development of biomarker-driven targeted therapy has resulted in substantial benefits for patients with non–small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations, and rearrangements involving the anaplastic lymph
Publikováno v:
JAMA. 317:1478
Publikováno v:
JAMA. 317:1477
Publikováno v:
JAMA. 317:1477
Autor:
Michael Gnant, Harald Anderson, Per-Uno Malmström, Richard Greil, Brigitte Mlineritsch, Jonas Bergh, Sibylle Loibl, Sabine Schmatloch, Volker Möbus, Tommy Fornander, Birgitta Wallberg, Lena M. S. Carlsson, Daniel Egle, Michael Untch, Nils-Olof Bengtsson, Yvonne Brandberg, Mats Hellström, Eva Karlsson, Hemming Johansson, Theodoros Foukakis, Christian F. Singer, Gunter von Minckwitz, Günther G. Steger
Publikováno v:
JAMA. 316:1888
Importance Standard dosing of chemotherapy based on body surface area results in marked interpatient variation in pharmacokinetics, toxic effects, and efficacy. Whether tailored dosing can improve outcomes is unknown, as is the role of dose-dense adj
Publikováno v:
JAMA. 315:2348