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Publikováno v:
JAMA Oncol
Importance In immune checkpoint inhibitor (ICI) trials, long tails and crossovers in survival curves—which violate the proportional hazards (PH) assumption—are commonly observed, making cure or restricted mean survival time models preferable for
Autor:
Luis Puig, Jose Bernabeu-Wittel, Ignasi Gich, Monica Rios, María Teresa Montserrat-García, Eulalia Baselga, Fania Zamantta Muñoz-Garza, Esther Roé-Crespo
Publikováno v:
JAMA Dermatol
JAMA DERMATOLOGY
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
JAMA Dermatology
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
JAMA DERMATOLOGY
r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname
r-FSJD: Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
Fundació Sant Joan de Déu
JAMA Dermatology
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
IMPORTANCE: Treatment of infantile hemangioma (IH) with topical timolol in the first 2 months of life (early proliferative phase) may prevent further growth and the need for treatment with oral propranolol. To our knowledge, no studies have determine
Autor:
Kunle Odunsi, Peter J. Frederick, Emese Zsiros, Chong Wang, Kristopher Attwood, Shashikant Lele, Eduardo Cortes Gomez, Shanmuga Reddy Chilakapati, Sarah Lynam, Song Liu, S.N. Akers
Publikováno v:
JAMA Oncol
Importance Treatment options for recurrent ovarian cancer are of limited clinical benefit and adversely affect patient quality of life, representing an unmet need for tolerable effective therapies. Objective To assess the efficacy and safety of a com
Autor:
Amit Maity, Alain H. Rook, Jennifer Villaseñor-Park, Carmela C. Vittorio, Kevin Zhang, Paul Haun, Sara A. Berg, Sara Samimi, Joanne Inverso, Daniel J. Lewis, Jaclyn Rosenthal, Christina A Del Guzzo, Ellen J. Kim, Maria Wysocka, Jessica E. Teague, Neha Jariwala, Bernice M. Benoit, Joseph S. Durgin, John P. Plastaras, Rachael A. Clark
Publikováno v:
JAMA Dermatol
Importance Sezary syndrome (SS) is an advanced form of cutaneous T-cell lymphoma with few long-term remissions observed. Objective To profile 3 patients with SS who have experienced long-term remission following the addition of low-dose total skin el
Autor:
Jake J. Lee, John S. Schneider, Dorina Kallogjeri, Jay F. Piccirillo, Murali M. Chakinala, Andrew M. Peterson
Publikováno v:
JAMA Otolaryngol Head Neck Surg
Importance Other than nasal moisturizers, no standard-of-care medical therapy exists for epistaxis in hereditary hemorrhagic telangiectasia (HHT). With epistaxis as the greatest cause of morbidity in patients with HHT, there is a need to identify eff
Autor:
Nina A. Karaseva, Sukrut Shah, Lucjan Wyrwicz, Joseph Chao, Christian Caglevic, Kohei Shitara, Luis Villanueva, Eric Van Cutsem, Al B. Benson, Eray Goekkurt, Wasat Mansoor, Marcelo Garrido, Iveta Kudaba, Keun Wook Lee, Jeeyun Lee, Maria Alsina, Andrew H. Ko, Charles S. Fuchs, S. Peter Kang, Josep Tabernero, Hugo Castro, Hironaga Satake, Uma Kher, Yung-Jue Bang, Maria Ignez Braghiroli, Peter C. Enzinger, Zev A. Wainberg, Hyun Cheol Chung
Publikováno v:
JAMA Oncology. 6:1571
Importance Safe and effective therapies for untreated, advanced gastric/gastroesophageal junction (G/GEJ) cancer remain an unmet need. Objective To evaluate the antitumor activity of pembrolizumab, pembrolizumab plus chemotherapy, or chemotherapy alo
Publikováno v:
JAMA Dermatology. 156:1117
Importance Certain patient groups, such as solid organ transplant recipients (SOTRs), have a significantly increased risk of developing skin cancers. The chemotherapeutic drug capecitabine has been used off label as a chemopreventive modality to supp
Autor:
Zoe B. Ciantra, Shana Criscitiello, Jason I. Kass, Jochen H. Lorch, Roy B. Tishler, Kai W. Wucherpfennig, Glenn J. Hanna, Nicole G. Chau, Adrienne M. Luoma, Ravindra Uppaluri, Danielle N. Margalit, Heather A. Jacene, Donald J. Annino, Anupam M. Desai, Bhupendra Rawal, Brendan Ross, Robert I. Haddad, Vickie Y. Jo, Jason L. Weirather, Ana Lako, Yu-Hui Chen, P.S. Catalano, Jonathan D. Schoenfeld, Hina Shah, Laura A. Goguen, Scott J. Rodig
Publikováno v:
JAMA Oncology. 6:1563
Importance Novel approaches are needed to improve outcomes in patients with squamous cell carcinoma of the oral cavity. Neoadjuvant immunotherapy given prior to surgery and combining programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte
Autor:
Linda Ahn, Maria E. Arcila, Hira Rizvi, Helena A. Yu, Glenn Heller, Michael F. Berger, Julie Li Yang, Jamie E. Chaft, Gregory J. Riely, Rachel Kim, Robert J. Young, Mark G. Kris, Alex Makhnin, Christina Falcon, Fanli Meng, Yosef Tobi, Brian Houck-Loomis, Adam J. Schoenfeld, Dana W.Y. Tsui, Marc Ladanyi, Sara A. Hayes
Publikováno v:
JAMA Oncol
IMPORTANCE: The combination of erlotinib and bevacizumab as initial treatment of epidermal growth factor receptor (EGFR [OMIM 131550])–mutant lung cancers improves progression-free survival (PFS) compared with erlotinib alone. Because osimertinib p
Autor:
Martin Sökler, Ulrich Keller, Carsten Kobe, Bastian von Tresckow, Andreas Rosenwald, Stephan Mathas, Paul J Bröckelmann, Michael Fuchs, Jasmin Mettler, Julia Meissner, Peter Borchmann, Andrea Kerkhoff, Andreas Zimmermann, Stephanie Sasse, Wolfram Klapper, Helen Goergen, Rainer Ordemann, Andreas Engert, Matthias Bormann, Teresa V Halbsguth, Christian Baues, Andreas Hüttmann
Publikováno v:
JAMA Oncol
Importance In early-stage unfavorable classic Hodgkin lymphoma (cHL), conventional therapy induces high cure rates but also relevant acute and long-term toxic effects. Nivolumab is well tolerated and highly effective in relapsed/refractory cHL but ha