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Autor:
Sefina Arif, Mark Peakman, Bart O. Roep, Arnoud H. de Ru, Jan W. Drijfhout, Jos Pool, Menno van Lummel, Peter A. van Veelen, Sandra Laban, Henk J. Aanstoot, Tatjana Nikolic, Iria Gomez-Tourino, Antoinette M. Joosten
Publikováno v:
Diabetes, 65(3), 732-741
Van Lummel, M, van Veelen, P A, de Ru, A H, Pool, J, Nikolic, T, Laban, S, Joosten, A, Drijfhout, J W, Gómez-Touriño, I, Arif, S, Aanstoot, H J, Peakman, M & Roep, B O 2016, ' Discovery of a selective islet peptidome presented by the highest-risk HLA-DQ8trans molecule ', Diabetes, vol. 65, no. 3, pp. 732-741 . https://doi.org/10.2337/db15-1031
Europe PubMed Central
Van Lummel, M, van Veelen, P A, de Ru, A H, Pool, J, Nikolic, T, Laban, S, Joosten, A, Drijfhout, J W, Gómez-Touriño, I, Arif, S, Aanstoot, H J, Peakman, M & Roep, B O 2016, ' Discovery of a selective islet peptidome presented by the highest-risk HLA-DQ8trans molecule ', Diabetes, vol. 65, no. 3, pp. 732-741 . https://doi.org/10.2337/db15-1031
Europe PubMed Central
HLA-DQ2/8 heterozygous individuals are at far greater risk for type 1 diabetes (T1D) development by expressing HLA-DQ8trans on antigen-presenting cells compared with HLA-DQ2 or -DQ8 homozygous individuals. Dendritic cells (DC) initiate and shape adap