Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Rudolph L. Leibel"'
Autor:
Matthew Freeby, Kazuhisa Watanabe, Robin Goland, Haiqing Hua, Matthew Zimmer, Wendy K. Chung, Linshan Shang, Hector Martinez, Dieter Egli, Rudolph L. Leibel, Kylie S. Foo, Charles A. LeDuc, David J. Kahler
Publikováno v:
Diabetes. 63:923-933
Wolfram syndrome is an autosomal recessive disorder caused by mutations in WFS1 and is characterized by insulin-dependent diabetes mellitus, optic atrophy, and deafness. To investigate the cause of β-cell failure, we used induced pluripotent stem ce
Autor:
Steven B. Heymsfield, Samuel Klein, David E. Kelley, Richard Kahn, Rudolph L. Leibel, David B. Allison, Cathy Nonas
Publikováno v:
Diabetes Care. 30:1647-1652
Obesity is an important risk factor for cardiometabolic diseases, including diabetes, hypertension, dyslipidemia, and coronary heart disease (CHD). Several leading national and international institutions, including the World Health Organization (WHO)
Autor:
Denis G. Baskin, Stephen C. Woods, Rudolph L. Leibel, Gregory S. Barsh, Michael W. Schwartz, Randy J. Seeley
Publikováno v:
Diabetes. 52:232-238
We describe a model of energy homeostasis to better understand neuronal pathways that control energy balance and their regulation by hormonal signals such as insulin and leptin. Catabolic neuronal pathways are those that both reduce food intake and i
Publikováno v:
Diabetes. 50:2268-2278
By supplying most organs of the body with metabolic substrates, the liver plays a central role in maintaining energy balance. Hepatic metabolism of glucose, fatty acids, and lipoproteins is disrupted in the leptin-deficient obese ( Lep ob / Lep ob )
Publikováno v:
Diabetes. 50:425-435
Mice homozygous for the Lepr db3J ( db 3J ) mutation are null for all known isoforms of the leptin receptor (LEPR). These animals are obese, hyperphagic, cold intolerant, insulin resistant, and infertile. Mice homozygous for the Lepr db ( db ) mutati
Autor:
Rudolph L. Leibel, X. Sharon Wu-Peng, Margery Nicolson, Shun Mei Liu, Norichika Okada, Streamson C. Chua
Publikováno v:
Diabetes. 46:513-518
The obese phenotypes of the diabetes ( db ) mouse and fatty ( fa ) rat are due to functional null mutations of the leptin receptor (Lepr). The recessive mutation in the Koletsky ( f ) obese rat maps to the same genetic intervals as db and fa and fail
Autor:
C Bogardus, Eric Ravussin, W. K. Chung, D B Thompson, R. A. Norman, William C. Knowler, Rudolph L. Leibel, Streamson C. Chua, Loraine Power-Kehoe
Publikováno v:
Diabetes. 45:1229-1232
The homologues of single genes that cause obesity in rodents are suggested as candidate genes for modulation of body composition in humans. Among these genes are the four mouse mutations—diabetes (db), obesity (ob), tubby (tub), and yellow agouti (
Autor:
Melinda S. Sothern, Bowie Kahle, Wendy K. Chung, Loraine Power-Kehoe, Melvin Chua, Louis J. Aronne, Zilla Huma, J. N. Udall, Rudolph L. Leibel, Florence Chu
Publikováno v:
Diabetes. 46:1509-1511
Autor:
Rudolph L. Leibel, Stuart P. Weisberg
Publikováno v:
Diabetes. 57:1-2
Progenitors of the nonobese diabetic mouse strain (NOD/Shi) arose spontaneously in a colony at the Shionogi Research Laboratories in Aburahi, Japan in the 1970s. The strain has been used extensively in efforts to elucidate the pathogenesis of type 1