Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Michael J. MacDonald"'
Publikováno v:
Diabetes. 70:1575-1580
Mitochondrial glycerol phosphate dehydrogenase (mGPD) is the rate-limiting enzyme of the glycerol phosphate redox shuttle. It was recently claimed that metformin, a first-line drug used for the treatment of type 2 diabetes, inhibits liver mGPD 30-50%
Mitochondrial glycerol phosphate dehydrogenase (mGPD) is the rate-limiting enzyme of the glycerol phosphate redox shuttle. It was recently claimed that metformin, a first line drug used for the treatment of type 2 diabetes, inhibits liver mGPD 30-50%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::621356ddd228268792ce65d7dd5b71da
https://doi.org/10.2337/figshare.14394359.v1
https://doi.org/10.2337/figshare.14394359.v1
Publikováno v:
Diabetes
Leucine is the only physiologic amino acid that can stimulate insulin release by itself, and a great deal of evidence suggests that leucine does this by allosterically activating glutamate dehydrogenase (GDH). GDH catalyzes the oxidative deamination
Autor:
Maciej T. Malecki, Sian Ellard, Donald F. Steiner, Julie Støy, Andrew Parrish, Louis H. Philipson, Graeme I. Bell, Maggie Shepherd, Ritika R. Kapoor, Sarah E. Flanagan, Chris Boustred, Michael J. MacDonald, Beverley M. Shields, Emma L. Edghill, Khalid Hussain, Andrew T. Hattersley, Ann-Marie Patch
Publikováno v:
Diabetes. 57:1034-1042
OBJECTIVE— Insulin gene (INS) mutations have recently been described as a cause of permanent neonatal diabetes (PND). We aimed to determine the prevalence, genetics, and clinical phenotype of INS mutations in large cohorts of patients with neonatal
Publikováno v:
Diabetes. 51:2669-2676
Nutrient secretagogues can increase the production of succinyl-CoA in rat pancreatic islets. When succinate esters are the secretagogue, succinyl-CoA can be generated via the succinate thiokinase reaction. Other secretagogues can increase production
Publikováno v:
Diabetes. 45:1626-1630
The enzyme activities of mitochondrial glycerol phosphate dehydrogenase (mGPD) (EC 1.1.99.5) and pyruvate carboxylase (PC) (EC 6.4.1.1) have been reported to be low in the pancreatic islet of several rodent models of NIDDM. The present study was unde
Publikováno v:
Diabetes. 46:1660-1661
Because the activity of mitochondrial glycerol phosphate dehydrogenase (mGPD) in the pancreatic β-cell is normally among the highest of the body, but is low in the pancreatic islets of numerous rodent models of NIDDM and is reported to be low in the
Publikováno v:
Diabetes Care. 16:1310-1311
Autor:
Michael J. MacDonald
Publikováno v:
Diabetes Care. 10:584-588
A new clinical entity that is prevalent in young type I (insulin-dependent) diabetic patients, postexercise late-onset (PEL) hypoglycemia, is described. A prospective case-finding study suggested that PEL hypoglycemia occurred in 48 of ∼300 diabeti
Publikováno v:
Diabetes. 36:265-268
Seasonality in the diagnosis of insulin-dependent diabetes mellitus (IDDM), i.e., increased incidence in winter, was the impetus for this study of seasonality in glycosylated hemoglobin levels in nondiabetics. Glycosylated hemoglobin levels of 35 non