Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Leslie A. Lange"'
Autor:
Maggie A. Stanislawski, Dana Dabelea, Jessica R Shaw, Ethan M. Lange, Kylie K. Harrall, Deborah H. Glueck, Leslie A. Lange, Sridharan Raghavan, Elizabeth Litkowski
Publikováno v:
Diabetes Care
OBJECTIVE The metabolic phenotype of youth-onset type 2 diabetes (T2D) differs from that of adult-onset T2D, but little is known about genetic contributions. We aimed to evaluate the association between a T2D genetic risk score (GRS) and traits relat
Autor:
the VA Million Veteran Program (MVP), Sridharan Raghavan, Richard L. Hauger, Leslie A. Lange, Lawrence S Phillips, Marijana Vujkovic, Julie A. Lynch, John E. Hokanson, Ethan M. Lange, Brian R Charest, Rui Zhang, Mark W. Logue, Elizabeth M Litkowski
Objective: Diabetes and dementia are diseases of high healthcare burden worldwide, and studies have shown that diabetes is associated with increased relative risk of dementia. We set out to examine whether type 2 diabetes-associated genetic variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd4f94ca4250a6ab4517b77bf904eb3
https://doi.org/10.2337/figshare.20427984
https://doi.org/10.2337/figshare.20427984
Autor:
Peitao Wu, Giulianini Franco, Daniel I. Chasman, Jerome I. Rotter, Georgy Hindy, Tom G. Richardson, M. Arfan Ikram, Ping An, Rafael R C Cuadrat, Jørgen K. Kanters, Sridharan Raghavan, Paul M. Ridker, Rita R. Kalyani, Jonas L. Isaksen, Morten S. Olesen, Xiuqing Guo, André G. Uitterlinden, Marju Orho-Melander, Lluís Masana, Lisa R. Yanek, Iyas Daghlas, Mohsen Ghanbari, Mary F. Feitosa, Jennifer A. Brody, Jose C Florez, Ulrika Ericson, James S. Floyd, Bianca Porneala, Jianwen Cai, Dhananjay Vaidya, Jee-Young Moon, James B. Meigs, George Davey Smith, Ching-Ti Liu, Susanne Jäger, Maryam Kavousi, Josée Dupuis, Christina Ellervik, Qibin Qi, Fariba Ahmadizar, Matthias B. Schulze, Mark O. Goodarzi, Dipender Gill, Josep M Mercader, Bruce M. Psaty, Laura M. Raffield, Leslie A. Lange, Colleen M. Sitlani, Robert C. Kaplan, Jie Yao, Jordi Merino, Michael A. Province
Publikováno v:
Wu, P, Moon, J-Y, Daghlas, I, Franco, G, Porneala, B C, Ahmadizar, F, Richardson, T G, Isaksen, J L, Hindy, G, Yao, J, Sitlani, C M, Raffield, L M, Yanek, L R, Feitosa, M F, Cuadrat, R R C, Qi, Q, Arfan Ikram, M, Ellervik, C, Ericson, U, Goodarzi, M O, Brody, J A, Lange, L, Mercader, J M, Vaidya, D, An, P, Schulze, M B, Masana, L, Ghanbari, M, Olesen, M S, Cai, J, Guo, X, Floyd, J S, Jäger, S, Province, M A, Kalyani, R R, Psaty, B M, Orho-Melander, M, Ridker, P M, Kanters, J K, Uitterlinden, A, Davey Smith, G, Gill, D, Kaplan, R C, Kavousi, M, Raghavan, S, Chasman, D I, Rotter, J I, Meigs, J B, Florez, J C, Dupuis, J, Liu, C-T & Merino, J 2022, ' Obesity Partially Mediates the Diabetogenic Effect of Lowering LDL Cholesterol ', Diabetes Care, vol. 45, no. 1, pp. 232-240 . https://doi.org/10.2337/dc21-1284
Diabetes Care
Diabetes Care, 45(1), 232-240. American Diabetes Association Inc.
Diabetes Care
Diabetes Care, 45(1), 232-240. American Diabetes Association Inc.
OBJECTIVE LDL cholesterol (LDLc)-lowering drugs modestly increase body weight and type 2 diabetes risk, but the extent to which the diabetogenic effect of lowering LDLc is mediated through increased BMI is unknown. RESEARCH DESIGN AND METHODS We cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ec7b0060cf74d3856c84b0064ada0e0
https://doi.org/10.2337/figshare.16826305.v1
https://doi.org/10.2337/figshare.16826305.v1
Autor:
Leslie A. Lange, Dana Dabelea, Ethan M. Lange, Deborah H. Glueck, Jessica Shaw, Kylie K. Harrall, Sridharan Raghavan, Elizabeth Litkowski, Maggie A. Stanislawski
Objective: The metabolic phenotype of youth-onset type 2 diabetes (T2D) differs from that of adult-onset T2D, but little is known about genetic contributions. We aimed to evaluate the association between a T2D genetic risk score (GRS) and traits rela
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17b9b59baee4ef27c6b7b9cb49288bfc
https://doi.org/10.2337/figshare.14731452.v1
https://doi.org/10.2337/figshare.14731452.v1
Autor:
Maggie A. Stanislawski, Kartik Shankar, Dana Dabelea, Brandy M. Ringham, Wei Perng, Catherine C. Cohen, Leslie A. Lange, Ann Scherzinger, Katherine A. Sauder, Anna Bellatorre
Publikováno v:
Diabetes. 70
Autor:
Deborah H. Glueck, Sridharan Raghavan, Maggie A. Stanislawski, Dana Dabelea, Ethan M. Lange, Elizabeth Litkowski, Leslie A. Lange, Kristen K. Harrall
Publikováno v:
Diabetes. 70
T2D prevalence has been increasing worldwide in both adults and youth. Youth-onset T2D is strongly associated with obesity and has been linked to increased morbidity and mortality. We aimed to evaluate the association between a T2D genetic risk score
Autor:
Suna Onengut-Gumuscu, Marian Rewers, Jill M. Norris, Zhennan Zhu, Wei-Min Chen, Leslie A. Lange, Andrea K. Steck, Stephen S. Rich, Bobbie-Jo M. Webb-Robertson, Kathleen Waugh, Brigitte I. Frohnert, Aakrosh Ratan, Umadevi Paila
Publikováno v:
Diabetes. 69
Background: Type 1 diabetes (T1D) is determined by unknown environmental factors in genetically susceptible individuals. The design of most genome wide association studies of T1D involves comparison of cases (with varying duration of disease) with co
Autor:
Charles Kooperberg, Josée Dupuis, JoAnn E. Manson, Peitao Wu, Jerome I. Rotter, Deirdre K Tobias, James B. Meigs, Sridharan Raghavan, Leslie A. Lange, Alexander G. Bick, Daniel DiCorpo, Laura M. Raffield
Publikováno v:
Diabetes. 69
Background and Objective: CHIP is the aging-related accumulation of genetic mutations in the hematopoiesis-associated genes of stem cells. CHIP was recently associated with total mortality and atherosclerotic cardiovascular disease. We tested the hyp
Autor:
Samuel S. Gidding, Jose C. Florez, Amy S. Shah, Shylaja Srinivasan, Morey W. Haymond, Nicola Santoro, Jasmin Divers, Leslie A. Lange, Jason Flannick, Santica M. Marcovina, Alan Chait, Sonia Caprio, Jennifer N. Todd, Brian Burke, Ling Chen
Publikováno v:
Diabetes. 68
Type 2 diabetes (T2D) in youth is associated with a pro-atherogenic lipid profile characterized by high triglycerides (TG), high low-density lipoprotein cholesterol (LDL-c), and low high-density lipoprotein cholesterol (HDL-c). Genome wide associatio
Publikováno v:
Diabetes
OBJECTIVE—The underlying genetic component of obesity-related traits is not well understood, and there is limited evidence to support genetic association shared across multiple studies, populations, and environmental contexts. The present study inv