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Publikováno v:
Diabetes
Peroxisome proliferator–activated receptor-α (PPARα) displays renoprotective effects with an unclear mechanism. Aberrant activation of the canonical Wnt pathway plays a key role in renal fibrosis. Renal levels of PPARα were downregulated in both
Autor:
Yong-Hoon Kim, Dongryeol Ryu, Seung Bum Park, Su Sung Kim, Chul-Ho Lee, Yo Na Kim, Gil Tae Gang, Inkyu Lee, Jin-Young Park, Cheol Soo Choi, Hueng Sik Choi, Minseob Koh, Taebo Sim, Seung Hoi Koo, Don Kyu Kim
Publikováno v:
Diabetes
Type 2 diabetes mellitus (T2DM) is a progressive metabolic disorder with diverse pathological manifestations and is often associated with abnormal regulation of hepatic glucose production. Many nuclear receptors known to control the hepatic gluconeog
Publikováno v:
Diabetes
OBJECTIVE Angiotensin (ANG) II interacts with insulin-signaling pathways to regulate insulin sensitivity. The type 1 (AT1R) and type 2 (AT2R) receptors reciprocally regulate basal perfusion of muscle microvasculature. Unopposed AT2R activity increase
Peroxisome Proliferator–Activated Receptor-γ Regulates Expression of PDX-1 and NKX6.1 in INS-1 Cells
Autor:
Ronak Desai, Jacob A. Moibi, Dhananjay Gupta, Mina Peshavaria, Jack L. Leahy, Thomas L. Jetton
Publikováno v:
Diabetes. 56:88-95
In the 60% pancreatectomy (Px) rat model of beta-cell adaptation, normoglycemia is maintained by an initial week of beta-cell hyperplasia that ceases and is followed by enhanced beta-cell function. It is unknown how this complex series of events is r
Autor:
Sulay Tovar, Mayte Alvarez-Crespo, Lucas C. González-Matías, Carlos Dieguez, Federico Mallo, Roberto Leiras, Diego Perez-Tilve
Publikováno v:
Diabetes. 56:143-151
Ghrelin is a potent orexigenic and adipogenic hormone that strongly influences fat deposition and the generation of hunger in obesity. Indeed, hyperghrelinemia appears to promote an increase in food intake as seen in Prader-Willi Syndrome (PWS). Exen
Autor:
Craig J. Gibson, Kathleen McGlynn, Michael C. Lawrence, Wei Chen, Colleen A. Vanderbilt, Tara Beers Gibson, Marlon F. Levy, Bashoo Naziruddin, Don Arnette, Melanie H. Cobb, Barbara E. Ehrlich, Julie Collins
Publikováno v:
Diabetes. 55:1066-1073
Glucose sensing is essential for the ability of pancreatic beta-cells to produce insulin in sufficient quantities to maintain blood glucose within the normal range. Stress causes the release of adrenergic hormones that increase circulating glucose by
Publikováno v:
Diabetes. 55:819-825
To better understand the insulin-independent plasma glucose–lowering action of metformin, we used streptozotocin (STZ)-induced diabetic rats to investigate the possible mechanisms. Oral intake of metformin decreased the plasma glucose of STZ-induce
Autor:
Karsten Buschard, Bryndis Birnir, S Albert Salehi, Sabine Sewing, Patrik Rorsman, Jesper Gromada, Anna Wendt, Matthias Braun
Publikováno v:
Diabetes. 53:1038-1045
gamma-Aminobutyric acid (GABA) has been proposed to function as a paracrine signaling molecule in islets of Langerhans. We have shown that rat beta-cells release GABA by Ca(2+)-dependent exocytosis of synaptic-like microvesicles. Here we demonstrate
Publikováno v:
Diabetes. 53:1074-1081
Hyperglycemia diminishes positive inotropic responses to agonists that activate phospholipase C (PLC) and generate inositol trisphosphate (1,4,5). The mechanisms underlying both the inotropic responses and hyperglycemia’s effects on them remain und
Publikováno v:
University of Copenhagen
Arginine-stimulated insulin and somatostatin release is enhanced by the sulfonylurea gliclazide. In contrast, gliclazide inhibits the glucagon response. The aim of the present study was to investigate whether this inhibition of glucagon release was m