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Autor:
Ole Gøtzsche
Publikováno v:
Diabetes. 32:1110-1116
The myocardial β-receptor adenylate cyclase system was investigated in short-term streptozotocin-diabetic rats. Earlier reports of a decreased sensitivity of the myocardium to isoproterenol (ISO) in these animals were elucidated by measuring the in
Autor:
Glenn T Hammons, Leonard Jarett
Publikováno v:
Diabetes. 29:475-486
In this study we used chloroquine to characterize the internalization and lysosomal degradation of receptorbound 125I-insulin by rat adipocytes and to determine the role of lysosomal processing of insulin in the shortterm biologic effects of the horm
Publikováno v:
Diabetes. 24:566-573
The degradation of insulin by isolated rat liver cells has been studied. The phenomenon is time- and temperature-dependent. After sixty minutes' exposure to 1.5 times 10-6 cells/ml, about 50 per cent, 15 per cent, and less than 5 per cent of insulin
Publikováno v:
Diabetes. 32:881-886
To more fully characterize the alterations in myocardial adrenergic and cholinergic receptors induced by the diabetic state, we investigated the binding characteristics of (–) [3H] dihydroalprenolol to beta adrenergic receptors (bAR), [3H] prazosin
Publikováno v:
Diabetes. 33:1062-1067
The receptor binding characteristics and biologic potency of biosynthetic human proinsulin (rDNA) were determined in isolated rat adipocytes and compared with those of insulin. In competition with 125I(A14)-iodoinsulin for binding to adipocyte recept
Publikováno v:
Diabetes. 36:1061-1067
Transplantation of a large inoculum of incubated islets of MHC-compatible donors led to an extended survival of the grafts to an average of >86 days in 71% of male diabetic BB/W recipients. Identical results were obtained whether the immunologically
Autor:
R. P. Robertson
Publikováno v:
Diabetes. 37:367-370
Eicosanoids both negatively and positively modulate glucose-induced insulin secretion. Although the identity of the positive modulator is uncertain, the negative modulator appears to be prostaglandin E 2 (PGE 2 ), because 1 ) glucose stimulates PGE 2
Publikováno v:
Diabetes. 33:339-345
It may now be possible to identify certain intracellular events that impact specifically on secretion-granule fusion to the plasma membrane or on granule lysis. Secretion vesicles in isolated rat islets appear to translocate somatostatin (SRIF) recep
Autor:
Bruce D. Cherksey, Norman Altszuler
Publikováno v:
Diabetes. 33:499-503
Previous in vivo findings indicated that alpha-adrenergic blocking agents enhanced tolbutamide-induced insulin secretion, whereas beta-blockade attenuated it. In the present study, the interaction of tolbutamide and glyburide with the rat islet adren
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