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Publikováno v:
Diabetes
OBJECTIVE Angiotensin (ANG) II interacts with insulin-signaling pathways to regulate insulin sensitivity. The type 1 (AT1R) and type 2 (AT2R) receptors reciprocally regulate basal perfusion of muscle microvasculature. Unopposed AT2R activity increase
Autor:
Je Kyung Seong, Kyung Jin Roh, Jae Woo Kim, Yong-Ho Ahn, Ji-Young Cha, So Youn Kim, Kang Yell Choi, Kyung-Sup Kim, Nam Taek Lee, Ha Il Kim
Publikováno v:
Diabetes. 51:676-685
Thiazolidinediones, synthetic ligands of peroxisomal proliferator-activated receptor-gamma (PPAR-gamma), improve peripheral insulin sensitivity and glucose-stimulated insulin secretion in pancreatic beta-cells. To explore the role of PPAR-gamma in gl
Autor:
Lucia Berti, Monika Kellerer, Luitgard Mosthaf, Stefanie Tippmer, Gerhild Kroder, Reinhard Kiehn, Hans U. Häring
Publikováno v:
Diabetes. 43:447-453
Troglitazone (CS045), a compound belonging to the thiazolidine diones, is being tested as a new oral antidiabetic agent. Evidence exists from animal studies and clinical trials with non-insulin-dependent diabetes mellitus patients that Troglitazone m