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Autor:
Alicia J. Jenkins, Robert Mott, Mingkai Lin, Yang Hu, Jian Xing Ma, Timothy J. Lyons, Anthony C Keech, Ying Chen
Publikováno v:
Diabetes
Retinal vascular leakage, inflammation, and neovascularization (NV) are features of diabetic retinopathy (DR). Fenofibrate, a peroxisome proliferator–activated receptor α (PPARα) agonist, has shown robust protective effects against DR in type 2 d
Autor:
Alan R. Prescott, Sandra Bacon, Lin Xue, Kashyap A. Patel, Lisa Logie, Kei Sakamoto, Hua Jiang, Katherine Macrae, Huan-Huan Wang, Graham Rena, Jean Harthill, D. Lee Hamilton, Gordon J. McDougall
Publikováno v:
Diabetes
In recent decades, the antihyperglycemic biguanide metformin has been used extensively in the treatment of type 2 diabetes, despite continuing uncertainty over its direct target. In this article, using two independent approaches, we demonstrate that
Autor:
James C. Engert, Ron Do, Changchun Xie, Salim Yusuf, Hertzel C. Gerstein, Sonia S. Anand, Bernard Keavney, Alexandre Montpetit, Swneke D. Bailey, Rafael Diaz, Viswanathan Mohan
Publikováno v:
Diabetes Care
OBJECTIVE Thiazolidinediones are used to treat type 2 diabetes. Their use has been associated with peripheral edema and congestive heart failure—outcomes that may have a genetic etiology. RESEARCH DESIGN AND METHODS We genotyped 4,197 participants