Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Xinxin Ding"'
Autor:
Chun-Yun Zhang, Xueshu Li, Kimberly P. Keil Stietz, Sunjay Sethi, Weizhu Yang, Rachel F. Marek, Xinxin Ding, Pamela J. Lein, Keri C. Hornbuckle, Hans-Joachim Lehmler
Publikováno v:
Environmental Science & Technology. 57:6251-6252
Publikováno v:
Chemical Research in Toxicology. 29:797-809
Albumin is a commonly used serum protein for studying human exposure to xenobiotic compounds, including therapeutics and environmental pollutants. Often, the reactivity of albumin with xenobiotic compounds is studied ex vivo with human albumin or pla
Publikováno v:
Chemical Research in Toxicology. 27:27-33
Pulmonary toxicity of styrene is initiated by cytochromes P450-dependent metabolic activation. P450 2E1 and P450 2F2 are considered to be two main cytochrome P450 enzymes responsible for styrene metabolism in mice. The objective of the current study
Publikováno v:
Chemical Research in Toxicology. 26:388-398
The herbicide 2,6-dichlorobenzonitrile (DCBN) is a potent nasal toxicant in rodents; however, it is not known whether DCBN causes similar nasal toxicity in humans. The tissue-selective toxicity of DCBN in mouse nasal mucosa is largely dependent on ta
Publikováno v:
Chemical Research in Toxicology. 23:1682-1690
3-Methylindole (3MI) is a preferential pneumotoxicant found in cigarette smoke. A number of lung-expressed human cytochrome P450 enzymes, including 1A1, 2F1, and 2A13, catalyze the metabolism of 3MI to reactive intermediates that fragment DNA – mea
Autor:
Sharon E. Murphy, Hansen L. Wong, Qing Yu Zhang, Xinxin Ding, Xiuling Zhang, Jun Gu, Stephen S. Hecht
Publikováno v:
Chemical Research in Toxicology. 18:913-918
Among human P450s studied to date, P450 2A13 is the most efficient catalyst of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) alpha-hydroxylation. This reaction is a key bioactivation pathway in NNK-induced carcinogenesis. P450 2A13 mRNA has be
Publikováno v:
Chemical Research in Toxicology. 17:502-511
Polychlorinated biphenyls are wide pollutants readily detected in environmental and human specimens. DNA adduction occurs through the corresponding quinones. Polychlorinated biphenyls are first metabolized to arene oxides, which can be further oxidiz
Publikováno v:
Chemical Research in Toxicology. 12:1254-1261
N-Nitrosobenzylmethylamine (NBzMA) is a potent and selective esophageal carcinogen in the rat and may be a causative agent for human esophageal cancer. This nitrosamine, like most, must be metabolically activated to exert its carcinogenic potential.