Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Ryo, Ito"'
Autor:
Ryo Ito, Yoshitomi Yayoi, Koji Watanabe, Teruki Hamada, Yasuhiro Hirata, Yasufumi Miyamoto, Seiji Miwatashi, Nobuyuki Takakura, Kazuaki Takami, Yoshihiko Hirozane, Naoyoshi Noguchi, Yusuke Moritoh, Mitsugi Ookawara, Hideki Furukawa, Jumpei Aida, Masanori Watanabe, Hitomi Yuko, Tsuyoshi Maekawa
Publikováno v:
Journal of Medicinal Chemistry. 63:10352-10379
GPR40/FFAR1 is a G-protein-coupled receptor expressed in pancreatic β-cells and enteroendocrine cells. GPR40 activation stimulates secretions of insulin and incretin, both of which are the pivotal regulators of glycemic control. Therefore, a GPR40 a
Autor:
Shuji Kitamura, Nobuyuki Negoro, Nobuhiro Suzuki, Tsuneo Yasuma, Yu Momose, Masami Suzuki, Naoyuki Kanzaki, Satoshi Mikami, Takashi Santou, Ryo Ito, Shinobu Sasaki, Takeshi Miyazaki, Junichi Miyazaki, Yoshiyuki Tsujihata, Toshimasa Tanaka, Miyuki Funami
Publikováno v:
Journal of Medicinal Chemistry. 55:3756-3776
As part of a program to identify potent GPR40 agonists with drug-like properties suitable for clinical development, the incorporation of polar substituents was explored with the intention of decreasing the lipophilicity of our recently disclosed phen
Autor:
Satoshi Mikami, Masami Suzuki, Yoshiyuki Tsujihata, Shinobu Sasaki, Takashi Santou, Masahiro Ito, Tomoyuki Odani, Toshimasa Tanaka, Nobuhiro Suzuki, Koji Takeuchi, Tsuneo Yasuma, Miyuki Funami, Shinichiro Matsunaga, Yu Momose, Junichi Miyazaki, Ryo Ito, Akifumi Kogame, Nobuyuki Negoro, Ayako Harada, Naoyuki Kanzaki
Publikováno v:
ACS Medicinal Chemistry Letters. 1:290-294
GPR40, one of the G protein-coupled receptors predominantly expressed in pancreatic β-cells, mediates enhancement of glucose-stimulated insulin secretion by free fatty acids. A potent and selective GPR40 agonist is theorized to be a safe and effecti