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pro vyhledávání: '"Jorge Cruz-Reyes"'
Autor:
Jana Gomez, Jair L. Siqueira-Neto, Drake M. Mellott, Jorge Cruz-Reyes, Emily Desormeaux, Claudia Calvet Alvarez, Jean A. Bernatchez, Thomas D. Meek, Linfeng Li, Xiang Zhai, Elizabeth Alvarez Hernandez, Balachandra Chenna, James H. McKerrow
Publikováno v:
J Med Chem
Cruzain, an essential cysteine protease of the parasitic protozoan, Trypanosoma cruzi, is an important drug target for Chagas disease. We describe here a new series of reversible but time-dependent inhibitors of cruzain, composed of a dipeptide scaff