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Publikováno v:
Chemical Research in Toxicology. 26:1642-1651
Mouse models are powerful tools to study the developmental neurotoxicity of polychlorinated biphenyls (PCBs); however, studies of the oxidation of chiral PCB congeners to potentially neurotoxic hydroxylated metabolites (OH-PCBs) in mice have not been
Publikováno v:
Chemical Research in Toxicology. 26:1378-1383
Nevirapine (NVP) can cause serious skin rashes and hepatotoxicity. It also causes an immune-mediated skin rash in rats but not hepatotoxicity. This rash is caused by a metabolite of NVP; specifically, NVP is oxidized in the liver to a benzylic alcoho
Autor:
Xiaohai Li, Michael D. Cameron
Publikováno v:
Chemical Research in Toxicology. 25:1004-1011
Clozapine was the first of the atypical antipsychotics to be developed, but its use has been restricted because of toxicity issues, particularly the risk of potentially life-threatening drug-induced neutropenia and agranulocytosis, which occurs in ab
Publikováno v:
Chemical Research in Toxicology. 21:1295-1303
2,2',3,3',6,6'-Hexachlorobiphenyl (PCB 136) is a chiral and highly neurotoxic PCB congener of environmental relevance. (+)-PCB 136 was previously shown to be enriched in tissues from mice treated with racemic PCB 136. We investigated the spectral int
Publikováno v:
Chemical Research in Toxicology. 21:869-873
The use of clozapine is limited by a relatively high incidence of drug-induced agranulocytosis. Clozapine is oxidized by bone marrow cells to a reactive nitrenium ion. Although many idiosyncratic drug reactions are immune-mediated, the fact that pati
Autor:
Mona I. Churchwell, Gonçalo Gamboa da Costa, Pedro C Pereira, Frederick A. Beland, M. Matilde Marques
Publikováno v:
Chemical Research in Toxicology. 20:300-310
Toremifene, an analogue of tamoxifen in which the ethyl side chain has been replaced with a 2-chloroethyl substituent, is used as a chemotherapeutic agent in postmenopausal women with advanced breast cancer. Toremifene is metabolized in a manner simi
Publikováno v:
Chemical Research in Toxicology. 19:1205-1214
Nevirapine, used for the treatment of HIV infection, is associated with development of skin rash and liver toxicity. The mechanism of these idiosyncratic reactions is unknown. We have previously reported the discovery of a new animal model of nevirap
Publikováno v:
Chemical Research in Toxicology. 18:1384-1394
Covalent binding of drug reactive metabolites to neutrophils or their precursors is thought to play a role in the development of drug-induced agranulocytosis. In this study, we used immunochemical techniques to compare the covalent binding of clozapi
Oxidation of Raloxifene to Quinoids: Potential Toxic Pathways via a Diquinone Methide and o-Quinones
Autor:
Wenkui Li, Fagen Zhang, Gregory R. J. Thatcher, Judy L. Bolton, Linning Yu, Hong Liu, Connie Luckie, Richard B. van Breemen
Publikováno v:
Chemical Research in Toxicology. 17:879-888
Raloxifene was approved in 1997 by the FDA for the treatment of osteoporosis in postmenopausal women, and it is currently in clinical trials for the chemoprevention of breast cancer. Before widespread use as a chemopreventive agent in healthy women,
Autor:
Subodh Kumar, Sumaira Munir, Atul Kumar, Zhi-Xin Yuan, and A. V. Muruganandam, Harish C. Sikka
Publikováno v:
Chemical Research in Toxicology. 16:1581-1588
Benzo[b]phenanthro[2,3-d]thiophene (BPT), a thia analogue of dibenz[a,h]anthracene (DBA), is a carcinogenic environmental pollutant. We have examined the metabolism of BPT by rodent liver microsomes to investigate the mechanism by which BPT produces