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Autor:
Zongjin Qu, Wenjie Zhao, Pengfei Shi, Jiaju Shi, Meiqi Shen, Jinhua Liu, Shusheng Zhang, Zichao Chen, Zhen Zhang, Mengting Zhu
Publikováno v:
ACS Applied Materials & Interfaces. 13:51393-51402
Telomerase and micro-RNAs (miRNAs) are simultaneously upregulated in a variety of tumor cells and have emerged as promising tumor markers. However, sensitive detection of telomerase and miRNAs in situ remains a great challenge due to their low expres
Autor:
Jhon R. Enterina, Matthew S. Macauley, Chris D. St. Laurent, Kay-Hooi Khoo, Abhishek Bhattacherjee, Chu-Wei Kuo, Wesley F. Zandberg, Fahima Mozaneh, Emily Rodrigues, Parisa Raeisimakiani, Gour Chand Daskhan, Jaesoo Jung, H Nitin, Po-Han Lin, Xuefei Huang, Lara K. Mahal, Duong T Bui, John S. Klassen
Publikováno v:
ACS Chemical Biology. 16:2673-2689
The immunomodulatory family of Siglecs recognize sialic acid-containing glycans as ‘self’, which is exploited in cancer for immune-evasion. The biochemical nature of Siglec ligands remains incompletely understood with emerging evidence suggesting
Autor:
Martijn R. H. Zwinderman, Peter M. Lansdorp, Marcel A. T. M. van Vugt, Petra E van der Wouden, Frank J. Dekker, Victor Guryev, Diana C.J. Spierings, Thamar Jessurun Lobo
Publikováno v:
ACS Chemical Biology
ACS chemical biology, 16(11), 2193-2201. AMER CHEMICAL SOC
ACS chemical biology, 16(11), 2193-2201. AMER CHEMICAL SOC
Following DNA replication, equal amounts of chromatin proteins are distributed over sister chromatids by re-deposition of parental chromatin proteins and deposition of newly synthesized chromatin proteins. Molecular mechanisms balancing the allocatio
Autor:
Maura Garofalo, Mattia Pedotti, Enrico M.A. Fassi, Andrea Cavalli, Mariagrazia Uguccioni, Valentina Cecchinato, Luca Varani, Jacopo Sgrignani, Luca Simonelli, Gabriela Danelon, Gianluca D'Agostino, Giovanni Grazioso
Publikováno v:
Journal of Medicinal Chemistry. 64:13439-13450
During inflammatory reactions, the production and release of chemotactic factors guide the recruitment of selective leukocyte subpopulations. The alarmin HMGB1 and the chemokine CXCL12, both released in the microenvironment, can form a heterocomplex,
Autor:
Naganna Nimishetti, Ziqi Yan, Hongmei Li, Thaddeus D. Allen, Vidhula Ahire, Qiong Shi, Jing Zhang, Dun Yang, Jinhua Li, Shenqiu Zhang
Publikováno v:
Journal of Natural Products. 84:2312-2320
To identify novel bioactive compounds, an image-based, cell culture screening of natural product extracts was conducted. Specifically, our screen was designed to identify phytochemicals that might phenocopy inhibition of the chromosomal passenger pro
Autor:
Robin Zinke, Barbara Klajnert-Maculewicz, Łukasz Pułaski, Maciej Studzian, Michał Gorzkiewicz, Izabela Jatczak-Pawlik, Dietmar Appelhans
Publikováno v:
Biomacromolecules
New therapeutic strategies for personalized medicine need to involve innovative pharmaceutical tools, for example, modular nanoparticles designed for direct immunomodulatory properties. We synthesized mannose-functionalized poly(propyleneimine) glyco
Publikováno v:
Biochemistry
The uptake of receptors by clathrin-mediated endocytosis underlies signaling, nutrient import, and recycling of transmembrane proteins and lipids. In the complex, crowded environment of the plasma membrane, receptors are internalized when they bind t
Publikováno v:
ACS Chemical Neuroscience. 12:872-882
Ginnalin A (GA), a polyphenol from the red maple, was reported to be a potential ROS scavenger or an activator of nuclear factor erythroid-2 related factor 2 (Nrf2) in cancer cells. However, whether GA could activate Nrf2 in neuronal cells and the ex
Publikováno v:
Analytical Chemistry. 93:2534-2540
MicroRNAs (miRNAs) play essential roles in regulating gene expression and cell fate. However, it remains a great challenge to image miRNAs with high accuracy in living cells. Here, we report a novel genetically encoded dual-color light-up RNA sensor
Autor:
Kai Jiang, Tony D. James, Hua Zhang, Yu F. Liu, Cong C. Shen, Jun W. Liu, Ge Wang, Yue H. Chen, Kui Wang, Yong G. Yang
Publikováno v:
Liu, J W, Yang, Y G, Wang, K, Wang, G, Shen, C C, Chen, Y H, Liu, Y F, James, T D, Jiang, K & Zhang, H 2021, ' Activation and Monitoring of mtDNA Damage in Cancer Cells via the "proton-Triggered" Decomposition of an Ultrathin Nanosheet ', ACS Applied Materials and Interfaces, vol. 13, no. 3, pp. 3669-3678 . https://doi.org/10.1021/acsami.0c20060
Mitochondrial DNA (mtDNA) damage is a very important molecular event, which has significant effects on living organisms. Therefore, a particularly important challenge for biomaterials research is to develop functionalized nanoparticles that can activ