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Autor:
Soonhag Kim, Byong Gon Park, Hyejung Heo, Yong Seung Lee, Woon Yong Jung, Min Geun Park, Seung Hun Oh
Publikováno v:
ACS Nano. 12:2531-2538
Exosomes, naturally secreted nanoparticles, have been introduced as vehicles for horizontal transfer of genetic material. We induced autologous exosomes containing a cocktail of reprogramming factors ("reprosomes") to convert fibroblasts into neural
Autor:
Vahid Sandoghdar, Michael Aigner, Katharina König, Matthew P. McDonald, André Gemeinhardt, Simon Völkl, Marek Piliarik, Stefanie Schaffer, Andreas Mackensen
Publikováno v:
Nano Letters. 18:513-519
Cellular secretion of proteins into the extracellular environment is an essential mediator of critical biological mechanisms, including cell-to-cell communication, immunological response, targeted delivery, and differentiation. Here, we report a nove
Autor:
Anjon Audhya, Timothy J. Smith, Ela W. Knapik, Michael G. Hanna, Gokhan Unlu, Brett M Condon, Nathan J. Cox, Thomas R. Meister, Abhishek Chhetri, Peter M Luo, Erik J. Soderblom, Brittany J. Bisnett, Michael Boyce
Publikováno v:
Biochemistry. 57:91-107
The COPII coat complex, which mediates secretory cargo trafficking from the endoplasmic reticulum, is a key control point for subcellular protein targeting. Because misdirected proteins cannot function, protein sorting by COPII is critical for establ
Autor:
Richa Sharma, Pushpangadan Indira Pradeepkumar, Ashan Manhas, Mohammad Anas, Niti Kumar, V. Dhamodharan, Kumkum Srivastava, Shakil Ahmed
Publikováno v:
Biochemistry. 56:6691-6699
The unique occurrence of G-quadruplexes in the AT-rich genome of human malaria parasite Plasmodium falciparum provides hints about their critical roles in parasite survival, pathogenesis, and host immune evasion. An intriguing question is whether the
Publikováno v:
ACS Chemical Neuroscience. 9:773-782
We studied the interactions of a tau derived hexapeptide AcPHF6 with β-amyloid peptides Aβ40 and Aβ42 which reveals its unusual ability to promote Aβ fibrillogenesis. The results demonstrate that the N-acetylated and C-amidated AcPHF6 hexapeptide
Autor:
Gonzalo Alba, Javier Saenz, Isabel Geniz, Consuelo Santa-María, María Edith Reyes-Quiroz, Francisco Sobrino, Juan Jimenez
Publikováno v:
Molecular Pharmaceutics. 15:1735-1745
The present work investigates the modulation of grapefruit flavonoid naringenin over liver X receptor alpha (LXRα) and its target genes in THP-1 macrophages, focusing on AMP-activated protein kinase (AMPK) implication. Naringenin induced LXRα at mR
Publikováno v:
ACS Synthetic Biology. 6:2191-2197
Mesenchymal stem cells (MSCs) are of interest in regenerative medicine owing to their multilineage differentiation and self-renewal properties. Understanding the in vivo differentiation process is necessary for clinical applications including cell th
Publikováno v:
Journal of Agricultural and Food Chemistry. 65:9763-9773
As a common polycyclic aromatic hydrocarbon compound, benzo[a]pyrene (BaP) is readily produced in processing of oil and fatty foods. It is not only a strong carcinogen but also a substance with strong immunotoxicity and reproduction toxicity. Autopha
Autor:
Tine Curk, Gerard C. L. Wong, Ernest Y. Lee, Toshiya Takahashi, Jure Dobnikar, Richard L. Gallo
Publikováno v:
ACS Nano. 11:12145-12155
Double-stranded RNA (dsRNA) induces production of pro-inflammatory cytokines in normal human epidermal keratinocytes (NHEK) by specific binding to endosomal Toll-like receptor-3 (TLR3). Recently, it has been shown that hyperactivation of TLR3 in psor
Publikováno v:
Biochemistry. 56:5526-5538
SM22α, also named transgelin, is an actin filament-associated protein in smooth muscle and fibroblasts. Three decades after its discovery, the biological function of SM22α remains under investigation. Here we report a novel finding that the express