Zobrazeno 1 - 10
of 64
pro vyhledávání: ''
Publikováno v:
Biochemistry
The uptake of receptors by clathrin-mediated endocytosis underlies signaling, nutrient import, and recycling of transmembrane proteins and lipids. In the complex, crowded environment of the plasma membrane, receptors are internalized when they bind t
Publikováno v:
ACS Chemical Neuroscience. 12:872-882
Ginnalin A (GA), a polyphenol from the red maple, was reported to be a potential ROS scavenger or an activator of nuclear factor erythroid-2 related factor 2 (Nrf2) in cancer cells. However, whether GA could activate Nrf2 in neuronal cells and the ex
Publikováno v:
ACS Chemical Biology. 15:3106-3111
Inositol-requiring enzyme 1α (IRE1α) is one of three endoplasmic reticulum stress sensors. Upon activation of its kinase domain, IRE1α splices the mRNA substrate XBP1, which activates the unfolded protein response. IRE1α has emerged as a therapeu
Autor:
Hye Gwang Jeong, Sun Woo Jin, Gi Ho Lee, Tuyet Ngan Thai, Ji Yeon Kim, Eun Hee Han, Chae Yeon Kim, Jae Ho Choi, Jin Song Park, Thi Hoa Pham
Publikováno v:
Journal of Agricultural and Food Chemistry. 68:14523-14530
Betulinic acid (BA) is a natural pentacyclic triterpenoid with protective effects against inflammation, metabolic diseases, and cardiovascular diseases. We have previously shown that BA prevents endothelial dysfunction by increasing nitric oxide (NO)
Autor:
Susan J. Kimber, Nicola Bates, Robert J. Lucas, Steven Woods, Christopher A. Smith, Paul A. Humphreys, Stuart A. Cain
Publikováno v:
Humphreys, P, Woods, S, Smith, C, Bates, N, Cain, S, Lucas, R & Kimber, S 2020, ' Optogenetic Control of the BMP Signaling Pathway ', ACS Synthetic Biology, vol. 9, no. 11, pp. 3067-3078 . https://doi.org/10.1021/acssynbio.0c00315
ACS Synthetic Biology
ACS Synthetic Biology
Bone morphogenetic proteins (BMPs) are members of the transforming growth factor β (TGFβ) superfamily and have crucial roles during development; including mesodermal patterning and specification of renal, hepatic, and skeletal tissues. In vitro dev
Publikováno v:
ACS Synthetic Biology
ACS synthetic biology, vol. 9, no. 8, pp. 2055-2065, 2020.
ACS synthetic biology, vol. 9, no. 8, pp. 2055-2065, 2020.
An important feature of synthetic biological circuits is their response to physicochemical signals, which enables the external control of cellular processes. Calcium-dependent regulation is an attractive approach for achieving such control, as divers
Publikováno v:
Journal of Agricultural and Food Chemistry. 67:9618-9629
Astrocytes provide nutritional support, regulate inflammation, and perform synaptic functions in the human brain. Although butylated hydroxyanisole (BHA) is a well-known antioxidant, several studies in animals have indicated BHA-mediated liver toxici
Autor:
Daniel Christ, Romain Rouet
Publikováno v:
ACS Chemical Biology. 14:554-561
We recently reported a new delivery system harnessing surface receptors for targeted uptake of CRISPR-Cas9 ribonucleoprotein into mammalian cells (Rouet et al., JACS 2018). For this purpose, Cas9 protein was labeled with the small molecule ligand ASG
Publikováno v:
Molecular Pharmaceutics. 15:2721-2731
Excessive or prolonged recruitment of inflammatory monocytes to damaged tissue can significantly worsen patient outcomes. Monocytes migrate to sites of tissue inflammation in response to high local concentrations of CCL2, a chemokine that binds to an
Publikováno v:
Journal of Agricultural and Food Chemistry. 66:5860-5870
Discovery of nutritionally available agents that could antagonize cisplatin-induced nephrotoxicity is of great significance and clinical application potential. 3,3'-Diselenodipropionic acid (DSePA) is a seleno-amino acid derivative that exhibits stro