Zobrazeno 1 - 5
of 5
pro vyhledávání: '"ZHAO LI"'
Publikováno v:
Biomacromolecules. 22:2224-2232
Cationic glycopolymers with structures similar to those of typical poly(ionic liquid)s (PILs) were synthesized via the quaternization reaction of poly(4-vinyl pyridine) with halogen-functionalized d-mannose and tetraphenylethylene units. Such postpol
Publikováno v:
ACS Biomaterials Science & Engineering. 5:2030-2040
The integration of nanomaterials with clinical therapeutic instruments is a promising approach to improve the effects of nanomaterials. We reported an efficient synergistic antibacterial strategy formed through the combination of Ag/ZnO nanocomposite
Publikováno v:
Journal of Chemical Information and Modeling. 55:2042-2049
Protein-protein interactions play key roles in a multitude of biological processes, such as de novo drug design, immune response, and enzymatic activity. It is of great interest to understand how proteins in a complex interact with each other. Here,
Exploring the S4 and S1 Prime Subsite Specificities in Caspase-3 with Aza-Peptide Epoxide Inhibitors
Autor:
Stjepan Jelakovic, Juliana L. Asgian, Markus G. Grütter, Rajkumar Ganesan, Zhao Zhao Li, Amy J. Campbell, James C. Powers
Publikováno v:
Biochemistry. 45:9059-9067
Caspase-3 is a prototypic executioner caspase that plays a central role in apoptosis. Aza-peptide epoxides are a novel class of irreversible inhibitors that are highly specific for clan CD cysteine proteases. The five crystal structures of caspase-3-
Autor:
Wendy Carter, Zhao Zhao Li, Jowita Mikolajczyk, Alan J. Barrett, James C. Powers, Juliana L. Asgian, Guy S. Salvesen, Karen Ellis James
Publikováno v:
Journal of Medicinal Chemistry. 45:4958-4960
Aza-peptide epoxides, a new class of irreversible protease inhibitors, are specific for the clan CD cysteine proteases. The inhibitors have second-order rate constants up to 10(5) M(-1) s(-1), with the most potent epoxides having the S,S stereochemis