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Autor:
Robin Zinke, Barbara Klajnert-Maculewicz, Łukasz Pułaski, Maciej Studzian, Michał Gorzkiewicz, Izabela Jatczak-Pawlik, Dietmar Appelhans
Publikováno v:
Biomacromolecules
New therapeutic strategies for personalized medicine need to involve innovative pharmaceutical tools, for example, modular nanoparticles designed for direct immunomodulatory properties. We synthesized mannose-functionalized poly(propyleneimine) glyco
Autor:
Martin Delguste, Florian Cotin, David Alsteens, Laurent Gillet, Grégoire Le Brun, Bénédicte Machiels
Publikováno v:
Nano Letters, Vol. 21, no. 1, p. 847-853 (2021)
Viruses are one of the most efficient pathogenic entities on earth, resulting from millions of years of evolution. Each virus particle carries the minimum number of genes and proteins to ensure their reproduction within host cells, hijacking some hos
Autor:
Pouya Faridi, Thomas P. Davis, Yanting Xing, Ava Faridi, Feng Ding, Anthony W. Purcell, Emily H. Pilkington, Ibrahim Javed, Aleksandr Kakinen, Aparna Nandakumar, Pu Chun Ke, Kairi Koppel, Ritchlynn Aranha
Publikováno v:
Biomacromolecules
Alzheimer’s disease (AD) is the most severe form of neurological disorder, characterized by the presence of extracellular amyloid-β (Aβ) plaques and intracellular tau tangles. For decades, therapeutic strategies against the pathological symptoms
Publikováno v:
Nano Letters. 19:5781-5789
Tissue-wide electrophysiology with single-cell and millisecond spatiotemporal resolution is critical for heart and brain studies. Issues arise, however, from the invasive, localized implantation of electronics that destroys well-connected cellular ne
Autor:
Akihiro Nishiguchi, Tetsushi Taguchi
Publikováno v:
Biomacromolecules. 20:1385-1393
An injectable bone may serve as a minimally invasive therapy for large orthopedic defects and osteoporosis and an alternative to allografting and surgical treatment. However, conventional bone substitutes lack the desirable biodegradability, biorespo
Autor:
Guodong Yang, Lianbi Zhao, Xiaotong Gao, Mengying Wei, Ruijing Shi, Zhelong Li, Wenqi Sun, Lijun Yuan, Yunyou Duan, Xueying Zhou
Publikováno v:
Nano Letters. 19:19-28
In vitro and in vivo delivery of RNAs of interest holds promise for gene therapy. Recently, exosomes are considered as a kind of rational vehicle for RNA delivery, especially miRNA and/or siRNA, while the loading efficiency is limited. In this study,
Autor:
Chang Tian, Wenming Liu, Yuanqing Wei, Jinyi Wang, Huaisheng Wang, Fen Zhang, Songqin Liu, Kan Wang
Publikováno v:
ACS Sensors. 3:2716-2725
Environmental pollution is one of the largest sources responsible for human diseases and premature death worldwide. However, the methodological development of a spatiotemporally controllable and high-throughput investigation of the environmental poll
Publikováno v:
Nano Letters. 18:7457-7468
Labeling and imaging with quantum dots (QDs) provides powerful tools to visualize viral infection in living cells. Encapsulating QDs within virions represents a novel strategy for virus labeling. Here, we developed infectious HIV-1 virions encapsulat
Autor:
Hanna Gerwien, Christian Paul Konken, Reshma Vidyadharan, Bernd Beutel, Lixia Li, Eva Korpos, Jian Song, Miriam Burmeister, Günter Haufe, Benjamin Schinor, Lydia Sorokin
Publikováno v:
Bioconjugate Chemistry. 29:3715-3725
Matrix metalloproteinases (MMPs) are emerging as pivotal fine-tuners of cell function in tissue homeostasis and in various pathologies, in particular inflammation. In vivo monitoring of the activity of specific MMPs, therefore, provides high potentia
Autor:
Francisco Javier de la Mata, Ma Jesús Serramía, Ingrid Araya-Durán, Rafael Gómez, Valeria Márquez-Miranda, Fernando D. González-Nilo, M. Ángeles Muñoz-Fernández, Carlos Guerrero-Beltrán, Ignacio Rodriguez-Izquierdo, Manuel Leal
Publikováno v:
Bioconjugate Chemistry. 29:1584-1594
Cell-to-cell transmission is the most effective pathway for the spread of human immunodeficiency virus (HIV-1). Infected cells expose virus-encoded fusion proteins on their surface as a consequence of HIV-1 replicative cycle that interacts with nonin