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Publikováno v:
ACS Chemical Biology. 16:1164-1171
By catalyzing a 3-3 cross-link in peptidoglycan, l,d-transpeptidases (Ldts) can cause resistance to β-lactams in some pathogens in vitro. However, the prevalence of Ldt and Ldt-mediated responses to different β-lactams in vivo have never been explo
Autor:
Yoshie Iizuka, Geoffrey Lang, Pamela M. England, Matthew P. Jacobson, Svetlana A. Kholodar, Harman S. Brah, Wilian A. Cortopassi
Publikováno v:
ACS Chem Biol
ACS chemical biology, vol 16, iss 7
ACS chemical biology, vol 16, iss 7
The nuclear receptor-related 1 protein, Nurr1, is a transcription factor critical for the development and maintenance of dopamine-producing neurons in the substantia nigra pars compacta, a cell population that progressively loses the ability to make
Autor:
Toshihiro Ihara, Hiroyasu Tsutsuki, Tianli Zhang, Takaaki Akaike, Yusuke Kitamura, Katsuhiko Ono, Azizur Rahman, Tomohiro Sawa
Publikováno v:
ACS Chemical Biology. 16:731-739
Hydrogen sulfide (H2S) formed during sulfur metabolism in bacteria has been implicated in the development of intrinsic resistance to antibacterial agents. Despite the conversion of H2S to hydropersulfides greatly enhancing the biochemical properties
Autor:
Ignacio Fernández, Fernando Sánchez-Santed, Ana Cristina Abreu, Cristian Perez Fernández, Miguel Morales Navas
Publikováno v:
ACS Chemical Biology. 16:753-765
NMR offers the unique potential to holistically screen hundreds of metabolites and has already proved to be a powerful technique able to provide a global picture of a wide range of metabolic processes underlying complex and multifactorial diseases, s
Autor:
Yuichiro Nakazawa, Akimasa Miyanaga, Fumitaka Kudo, Genzoh Tanabe, Fumihiro Ishikawa, Yoko Nagumo, Naeko Iwai, Yuki Hayakawa, Koichi Kawamura, Sotaro Takahashi, Tadashi Eguchi, Kota Nishino, Takeo Usui
Publikováno v:
ACS Chemical Biology. 16:539-547
Hitachimycin is a macrolactam antibiotic with an (S)-β-phenylalanine (β-Phe) at the starter position of its polyketide skeleton. (S)-β-Phe is formed from l-α-phenylalanine by the phenylananine-2,3-aminomutase HitA in the hitachimycin biosynthetic
Autor:
Mohammad R. Seyedsayamdost, Étienne Gallant, Aya Yoshimura, Anran Li, Chen Zhang, Brett C. Covington
Publikováno v:
ACS Chem Biol
The products of most secondary metabolite biosynthetic gene clusters (BGCs) have yet to be discovered, in part due to low expression levels in laboratory cultures. Reporter-guided mutant selection (RGMS) has recently been developed for this purpose:
Publikováno v:
ACS Chemical Biology. 15:1765-1772
Dinucleoside polyphosphates (NpnNs) were discovered 50 years ago in all cells. They are often called alarmones, even though the molecular target of the alarm has not yet been identified. Recently, we showed that they serve as noncanonical initiating
Publikováno v:
ACS Chemical Biology. 15:1242-1251
Selective chemical probes enable individual investigation of penicillin-binding proteins (PBPs) and provide critical information about their enzymatic activity with spatial and temporal resolution. To identify scaffolds for novel probes to study pept
Publikováno v:
ACS Chemical Biology. 15:74-82
The limited therapeutic options and increasing drug-resistance call for next-generation influenza antivirals. Due to the essential function in viral replication and high sequence conservation among influenza viruses, influenza polymerase PA-PB1 prote
Publikováno v:
ACS Chemical Biology. 14:2065-2070
The emergence of multi-drug-resistant Gram-negative bacteria, including carbapenem-resistant Enterobacteriaceae, is a major health problem that necessitates the development of new antibiotics. Vancomycin inhibits cell-wall synthesis in Gram-positive