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Publikováno v:
ACS Chemical Neuroscience
The SARS-CoV-2 virus is notorious for its neuroinvasive capability, causing multiple neurological conditions. The neuropathology of SARS-CoV-2 is increasingly attributed to mitochondrial dysfunction of brain microglia cells. However, the changes in b
Autor:
R. Luke Wiseman, Gabriel Kline, Kayla Nutsch, Michael J. Bollong, Jessica D. Rosarda, Kelsey R. Baron, Caroline Stanton, Jeffery W. Kelly
Publikováno v:
ACS Chemical Biology
The extracellular accumulation of glutamate is a pathologic hallmark of numerous neurodegenerative diseases including ischemic stroke and Alzheimer's disease. At high extracellular concentrations, glutamate causes neuronal damage by promoting oxidati
Autor:
Mina Aleemardani, Sara Simorgh, Raziyeh Najafloo, Alimohamad Asghari, Jila Majidi, Seyed Kamran Kamrava, Amelia Seifalian, Zohreh Bagher, Alexander M. Seifalian
Publikováno v:
ACS Chemical Neuroscience
The occurrence of anosmia, the loss or change in sense of smell, is one of the most common symptoms of COVID-19 experienced by almost 53% of those affected. Several hypotheses explain the mechanism of anosmia in patients suffering from COVID-19. This
Publikováno v:
ACS Nano
bioRxiv
bioRxiv
The nanoscale spatial organization of transmembrane tumor necrosis factor (TNF) receptors has been implied as a regulator of cellular fate. Accordingly, molecular tools that can induce specific arrangements of these receptors on cell surfaces would g
Autor:
Shibin Chacko, Bryce R Blankenfeld, Chamani Perera, David J. Ingham, Berl R. Oakley, Truman Christopher Gamblin
Publikováno v:
Biochemistry
The microtubule-associated protein tau promotes the stabilization of the axonal cytoskeleton in neurons. In several neurodegenerative diseases, such as Alzheimer's disease, tau has been found to dissociate from microtubules, leading to the formation
Publikováno v:
Biomacromolecules
The apparent rise of bone disorders demands advanced treatment protocols involving tissue engineering. Here, we describe self-assembling tetrapeptide scaffolds for the growth and osteogenic differentiation of human mesenchymal stem cells (hMSCs). The
Autor:
Giulia Vecchi, Christopher M. Dobson, Roberta Cascella, Michele Vendruscolo, Cristina Cecchi, Benedetta Mannini, Fabrizio Chiti, Giulia Fani
Publikováno v:
ACS Chemical Neuroscience
Alzheimer's disease, which is the most common form of dementia, is characterized by the aggregation of the amyloid β peptide (Aβ) and by an impairment of calcium homeostasis caused by excessive activation of glutamatergic receptors (excitotoxicity)
Publikováno v:
Journal of the American Chemical Society
Journal of the American Chemical Society, vol 143, iss 2
Journal of the American Chemical Society, vol 143, iss 2
Targeted protein degradation has emerged as a new paradigm to manipulate cellular proteostasis. Proteolysis-targeting chimeras (PROTACs) are bifunctional small molecules that recruit an E3 ligase to a target protein of interest, promoting its ubiquit
Autor:
Lars Farde, Christer Halldin, Sangram Nag, Katarina Varnäs, Zhisheng Jia, Sajinder K. Luthra, Rabia Ahmad, Alex Jackson, Marie Svedberg
Publikováno v:
ACS Chemical Neuroscience
Monoamine oxidase B (MAO-B) is an important enzyme regulating the levels of monoaminergic neurotransmitters. Selective MAO-B inhibitors have been labeled with carbon-11 or fluorine-18 to visualize the localization of MAO-B in vivo by positron emissio
Rhodopsin (RHO) is a light-sensitive pigment in the retina and the main prototypical protein of the G-protein-coupled receptor (GCPR) family. After receiving a light stimulus, RHO and its cofactor retinylidene undergo a series of structural changes t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62122bd26f4ccc532fa82b7b22fefdaf
http://hdl.handle.net/10261/310668
http://hdl.handle.net/10261/310668