Zobrazeno 1 - 10
of 114
pro vyhledávání: ''
Publikováno v:
ACS Chemical Neuroscience
The SARS-CoV-2 virus is notorious for its neuroinvasive capability, causing multiple neurological conditions. The neuropathology of SARS-CoV-2 is increasingly attributed to mitochondrial dysfunction of brain microglia cells. However, the changes in b
Autor:
R. Luke Wiseman, Gabriel Kline, Kayla Nutsch, Michael J. Bollong, Jessica D. Rosarda, Kelsey R. Baron, Caroline Stanton, Jeffery W. Kelly
Publikováno v:
ACS Chemical Biology
The extracellular accumulation of glutamate is a pathologic hallmark of numerous neurodegenerative diseases including ischemic stroke and Alzheimer's disease. At high extracellular concentrations, glutamate causes neuronal damage by promoting oxidati
Autor:
Mina Aleemardani, Sara Simorgh, Raziyeh Najafloo, Alimohamad Asghari, Jila Majidi, Seyed Kamran Kamrava, Amelia Seifalian, Zohreh Bagher, Alexander M. Seifalian
Publikováno v:
ACS Chemical Neuroscience
The occurrence of anosmia, the loss or change in sense of smell, is one of the most common symptoms of COVID-19 experienced by almost 53% of those affected. Several hypotheses explain the mechanism of anosmia in patients suffering from COVID-19. This
Autor:
Giulia Vecchi, Christopher M. Dobson, Roberta Cascella, Michele Vendruscolo, Cristina Cecchi, Benedetta Mannini, Fabrizio Chiti, Giulia Fani
Publikováno v:
ACS Chemical Neuroscience
Alzheimer's disease, which is the most common form of dementia, is characterized by the aggregation of the amyloid β peptide (Aβ) and by an impairment of calcium homeostasis caused by excessive activation of glutamatergic receptors (excitotoxicity)
Autor:
Lars Farde, Christer Halldin, Sangram Nag, Katarina Varnäs, Zhisheng Jia, Sajinder K. Luthra, Rabia Ahmad, Alex Jackson, Marie Svedberg
Publikováno v:
ACS Chemical Neuroscience
Monoamine oxidase B (MAO-B) is an important enzyme regulating the levels of monoaminergic neurotransmitters. Selective MAO-B inhibitors have been labeled with carbon-11 or fluorine-18 to visualize the localization of MAO-B in vivo by positron emissio
Publikováno v:
ACS Chemical Neuroscience
Immune system and renin-angiotensin-aldosterone system dysregulation with associated cytokine release syndrome may be a key feature of early stage of SARS-CoV-2 organotropism and infection. Following viral mediated brain injury, dysregulated neuroche
Publikováno v:
ACS Chemical Neuroscience
Intraneuronal accumulation of amyloid-β (Aβ) is an early pathological signum of Alzheimer's disease, and compartments of the endolysosomal system have been implicated in both seeding and cell-cell propagation of Aβ aggregation. We have studied how
Publikováno v:
ACS Chemical Biology
Malaria remains an endemic tropical disease, and the emergence of Plasmodium falciparum parasites resistant to current front-line medicines means that new therapeutic targets are required. The Plasmodium glideosome is a multiprotein complex thought t
Autor:
Michal Baram, Yifat Miller
Publikováno v:
ACS Chemical Neuroscience
Clinical trials of intranasal insulin treatment for Alzheimer's patients have shown cognitive and memory improvement, but the effect of insulin has shown a limitation. It was suggested that insulin molecule binds to Aβ aggregates and impedes Aβ agg
Publikováno v:
ACS Chemical Biology
ACS Chemical Biology, 14(11), 2389-2395
ACS Chemical Biology, 14(11), 2389-2395
SUMOylation is a reversible and highly dynamic post-translational modification of target proteins by small ubiquitin-like modifiers (SUMO). It is orchestrated by SUMO-activating, -conjugating, and -ligating enzymes in a sequential manner and is impor