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Publikováno v:
ACS Chemical Biology
Malaria remains an endemic tropical disease, and the emergence of Plasmodium falciparum parasites resistant to current front-line medicines means that new therapeutic targets are required. The Plasmodium glideosome is a multiprotein complex thought t
Autor:
Joost P.G. Sluijter, Linglei Jiang, Raymond M. Schiffelers, Daniel E. Murphy, Sander A.A. Kooijmans, Olivier G. de Jong, Martijn J W Evers, Pieter Vader
Publikováno v:
Accounts of Chemical Research
[Image: see text] Extracellular vesicles are nanoparticles produced by cells. They are composed of cellular membrane with associated membrane proteins that surrounds an aqueous core containing soluble molecules such as proteins and nucleic acids, lik
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f79b9c44bab21c43fd6245034db7b5c
https://europepmc.org/articles/PMC6639984/
https://europepmc.org/articles/PMC6639984/
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
ACS Chemical Neuroscience
instname
ACS Chemical Neuroscience
While alcohol’s detrimental effects on the brain are widely acknowledged, diagnostic markers for detection and monitoring alcohol-induced brain damage are lacking. A recent study showed that diffusion tensor imaging can be used to monitor this dama
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b404b973fa35b29da013191183c3e9b9
http://hdl.handle.net/10261/217779
http://hdl.handle.net/10261/217779
Autor:
Carlota Tosat-Bitrián, Valle Palomo, Ángeles Martín-Requero, Vanesa Nozal, Siranjeevi Nagaraj, Ana Martínez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
ACS Chemical Neuroscience
instname
ACS Chemical Neuroscience
48 p.-7 fig.-1 graph. abst.
Accumulation of TDP-43 in the cytoplasm of diseased neurons is the pathological hallmark of frontotemporal dementia-TDP (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), two diseases that lack efficacious medicine t
Accumulation of TDP-43 in the cytoplasm of diseased neurons is the pathological hallmark of frontotemporal dementia-TDP (FTLD-TDP) and amyotrophic lateral sclerosis (ALS), two diseases that lack efficacious medicine t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816f8eb6049a0b84b199cab5a919c708
http://hdl.handle.net/10261/178631
http://hdl.handle.net/10261/178631
Autor:
Laura Tosatto, Mathew H. Horrocks, Joseph S Beckwith, Michael J. Devine, Henrik Zetterberg, Steven F. Lee, Nicholas W. Wood, Nadia K. Magdalinou, Serene W. Chen, Marija Iljina, Magnus Kjaergaard, Christopher M. Dobson, Nunilo Cremades, Sonia Gandhi, David Klenerman
Publikováno v:
ACS Chemical Neuroscience
The misfolding and aggregation of proteins into amyloid fibrils characterizes many neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. We report here a method, termed SAVE (single aggregate visualization by enhancement) imaging,
Publikováno v:
ACS Chemical Neuroscience
Anesthetics are thought to mediate a portion of their activity via binding to and modulation of potassium channels. In particular, tandem pore potassium channels (K2P) are transmembrane ion channels whose current is modulated by the presence of gener
Autor:
Lurdes Gano, Célia Fernandes, Diana Gaspar, Miguel A. R. B. Castanho, Vera Neves, Maurício Morais, Frederico Aires-da-Silva, Elisabete Ribeiro, Antónia R. T. Pinto, Sandra I Aguiar, João D. G. Correia
Publikováno v:
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ACS Chemical Biology
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ACS Chemical Biology
© 2017 American Chemical Society
The delivery of therapeutic molecules to the central nervous system is hampered by poor delivery across the blood-brain barrier (BBB). Several strategies have been proposed to enhance transport into the brain, i
The delivery of therapeutic molecules to the central nervous system is hampered by poor delivery across the blood-brain barrier (BBB). Several strategies have been proposed to enhance transport into the brain, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c467098dda13148c235df6d17b166d5
Autor:
Marc B. Cox, Maulik R. Patel, Pallav D. Patel, Liza Shrestha, Yanlong Kang, Tony Taldone, Erica DaGama Gomes, Monica L. Guzman, Alexander Gozman, Gabriela Chiosis, Ronnie Maharaj, Hediye Erdjument-Bromage, Anna Rodina, Cristina Santarossa, Ronald C. Hendrickson, Pengrong Yan, John Koren, Ari Melnick, Chenghua Yang, Stefan O. Ochiana, Leandro Cerchietti
Publikováno v:
ACS Chemical Biology
Heat shock protein 70 (Hsp70) is a family of proteins with key roles in regulating malignancy. Cancer cells rely on Hsp70 to inhibit apoptosis, regulate senescence and autophagy, and maintain the stability of numerous onco-proteins. Despite these imp
Autor:
Joseph Sodroski, Wayne A. Hendrickson, Amos B. Smith, Ernesto Freire, Joel R. Courter, Irwin Chaiken, Peter D. Kwong, Judith M. LaLonde, Navid Madani, Arne Schön
Publikováno v:
Accounts of Chemical Research
Conspectus This Account provides an overview of a multidisciplinary consortium focused on structure-based strategies to devise small molecule antagonists of HIV-1 entry into human T-cells, which if successful would hold considerable promise for the d
Publikováno v:
ACS Chemical Biology
Cellular inhibitor of apoptosis protein 1 and 2 (cIAP1/2) and X-linked inhibitor of apoptosis protein (XIAP) are key apoptosis regulators and promising new cancer therapeutic targets. This study describes a set of non-peptide, small-molecule Smac (se