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pro vyhledávání: '"Marc K. Halushka"'
Autor:
Harry C. Dietz, Megan Podowski, Marc K. Halushka, Kathleen L. Gabrielson, Tammy M. Holm, Erin C Klein, Djahida Bedja, David L. Huso, Loretha Myers, Timothy K. Cooper, Luca Carta, Francesco Ramirez, Carla L. Calvi, Ronald D. Cohn, Bart Loeys, Daniel B. Rifkin, Enid Neptune, Daniel P. Judge, Jennifer P Habashi, Guosheng Liu
Publikováno v:
Science. 312:117-121
Aortic aneurysm and dissection are manifestations of Marfan syndrome (MFS), a disorder caused by mutations in the gene that encodes fibrillin-1. Selected manifestations of MFS reflect excessive signaling by the transforming growth factor–β (TGF-β