Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Charles Swanton"'
Autor:
William Grey, Ana Rio-Machin, Pedro Casado, Eva Grönroos, Sara Ali, Juho J. Miettinen, Findlay Bewicke-Copley, Alun Parsons, Caroline A. Heckman, Charles Swanton, Pedro R. Cutillas, John Gribben, Jude Fitzgibbon, Dominique Bonnet
Publikováno v:
Science Translational Medicine. 14
Acute myeloid leukemia (AML) is an aggressive hematological disorder comprising a hierarchy of quiescent leukemic stem cells (LSCs) and proliferating blasts with limited self-renewal ability. AML has a dismal prognosis, with extremely low 2-year surv
Autor:
Dhira Joshi, Lucy R. Marshall, Lucy R. Wedderburn, Stavroula Paraskevopoulou, Steve Gamblin, Georgina H. Cornish, Sonia Gandhi, Charles Swanton, John W. McCauley, William Bolland, Svend Kjaer, Nikhil Faulkner, Hannah Rickman, Rachel Ulferts, Philip Hobson, D.J. Benton, Laura E. McCoy, Ana Agua-Doce, Rupert Beale, Annachiara Rosa, Chloe Roustan, Nicola O’Reilly, Catherine F Houlihan, Christopher Earl, Eleni Nastouli, A.G. Wrobel, Rachael Thompson, Brigitta Stockinger, Kirsty Thomson, Catherine Moore, Bethany R. Jebson, Anna Radziszewska, Coziana Ciurtin, Andrew Riddell, Saira Hussain, Emilie Sanchez, Peter Cherepanov, Elizabeth C. Rosser, Meredyth G. Ll Wilkinson, Kevin W. Ng, Ruth Harvey, Philip A. Walker, Hannah Peckham, Judith Heaney, Gee Yen Shin, Moira J. Spyer, George Kassiotis
Publikováno v:
Science (New York, N.y.)
Science
Science
Antibodies predating infection Immunological memory after infection with seasonal human coronaviruses (hCoVs) may potentially contribute to cross-protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Ng et al. report that i
Autor:
Hans Clevers, Marc van de Wetering, Martin A. Nowak, Jochen K. Lennerz, Kamila Naxerova, Rakesh K. Jain, Charles Swanton, Tianxi Cai, Elena F. Brachtel, Stephen J. Elledge, Andrew Rowan, Johannes G. Reiter
Publikováno v:
Science, 357(6346), 55-60. American Association for the Advancement of Science (AAAS)
Science, 357(6346), 55. American Association for the Advancement of Science
Science, 357(6346), 55. American Association for the Advancement of Science
Metastases undergo reconstruction Cancer cells from primary tumors can migrate to regional lymph nodes and distant organs. The prevailing model in oncology is that lymph node metastases give rise to distant metastases. This “sequential progression
Autor:
Charles Swanton, Samra Turajlic
Publikováno v:
Science. 352:169-175
Therapeutic advances in oncology have not fully translated to the treatment of metastatic disease, which remains largely incurable. Metastatic subclones can emerge both early and late in the life of the primary tumor. A better understanding of the ge
Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
Autor:
Nicholas McGranahan, Francesco Favero, Zoltan Szallasi, Elza C de Bruin, Charles Swanton, Nicolai Juul Birkbak
Publikováno v:
Science Translational Medicine. 7
Deciphering whether actionable driver mutations are found in all or a subset of tumor cells will likely be required to improve drug development and precision medicine strategies. We analyzed nine cancer types to determine the subclonal frequencies of