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Autor:
Noy Cohen Saban, Adam Yalin, Tomer Landsberger, Ran Salomon, Ajjai Alva, Tali Feferman, Ido Amit, Rony Dahan
Publikováno v:
Science Immunology. 8
FDA-approved anti–PD-L1 monoclonal antibodies (mAbs) bear the IgG1 isotype, whose scaffolds are either wild-type (e.g., avelumab) or Fc-mutated and lacking Fcγ receptor (FcγR) engagement (e.g., atezolizumab). It is unknown whether variation in th