Zobrazeno 1 - 10
of 11
pro vyhledávání: '"M. Allen"'
Autor:
Kole T. Roybal, Wendell A. Lim, Cristina Puig-Saus, Vivian P. Garcia, Greg M. Allen, Devan Shah, Antoni Ribas, Gavin E. Shavey, Jasper Z. Williams, Igal S. Sterin, Wei Yu, Jennifer Tsoi, Ki H. Kim
Publikováno v:
Science (New York, N.Y.), vol 370, iss 6520
Science
Science
A logic to cell-cell recognition There has been exciting progress in the field of cancer immunotherapy, which harnesses a patient's own immune system to kill cancer cells. However, achieving precise recognition of cancer cells remains challenging. Ce
Autor:
David R. Collins, Michael T. Waring, Gaurav D. Gaiha, Olivia Mae Waring, Todd M. Allen, Bruce D. Walker, Karen A. Power, Jonathan M. Urbach, Musie Ghebremichael, Daniel P Worrall, Elizabeth J. Rossin, James Chodosh, Itai Muzhingi, Chioma Nwonu, Melis N. Anahtar, Christian Landeros, Alicja Piechocka-Trocha, Ruchi M. Newman
Publikováno v:
Science. 364:480-484
Structure-based immunogen design Vaccine design for highly mutable pathogens is hindered by a paucity of conserved immunogenic epitopes. Gaiha et al. employed a structure-based technique using network theory to assign scores to protein structure in o
Autor:
Paul M. Allen, Marta Wegorzewska, Samantha Hsieh, Stephen Horvath, Robert W. P. Glowacki, Eric C. Martens, Christina A. Hickey, David L. Donermeyer, Thaddeus S. Stappenbeck
Publikováno v:
Science Immunology. 4
T cell responses to symbionts in the intestine drive tolerance or inflammation depending on the genetic background of the host. These symbionts in the gut sense the available nutrients and adapt their metabolic programs to use these nutrients efficie
Publikováno v:
Science. 281:572-575
The T cell receptor (TCR) αβ heterodimer interacts with its ligands with high specificity, but surprisingly low affinity. The role of the ζ component of the murine TCR in contributing to the fidelity of antigen recognition was examined. With seque
Publikováno v:
Science Translational Medicine. 5
Acute graft-versus-host disease (aGVHD) results from a robust response of donor T cells transferred during hematopoietic stem cell transplantation (HSCT) to allogeneic peptide-major histocompatibility complex antigens. Previous investigations have no
Autor:
Priyasma Bhoumik, Xiaojiang Gao, Lena Fadda, Laura Battis, Marcus Altfeld, Todd M. Allen, Andrew D. Luster, Trevor Tivey, Vladimir Vrbanac, Karen A. Power, Andrew M. Tager, Edward Seung, Elizabeth F. Mellors, Timothy Dudek, Adrianne D. Gladden, Daniel C. No, Christian L. Boutwell
Publikováno v:
Science Translational Medicine. 4
Important advancements in the development of novel mouse/human chimeras through the engraftment of human immune cells and tissues into immunodeficient mice, including the recently described humanized BLT mouse model, holds great promise to facilitate
Autor:
Brian D. Evavold, Paul M. Allen
Publikováno v:
Science. 252:1308-1310
In the presence of antigen presenting cells, a murine T helper (Th) cell specific for murine hemoglobin (Hb) responded to its immunogenic peptide by both cytokine (interleukin-4) secretion and proliferation. An altered Hb peptide with a single amino
Autor:
Emil R. Unanue, Paul M. Allen
Publikováno v:
Science. 236:551-557
Macrophages handle extracellular proteins and secrete diverse bioactive molecules and, therefore, influence the physiology of many tissues. They also have an important immunoregulatory role. The immune response to proteins involves the activation of
Autor:
Margaret E. Beard, John M. Allen
Publikováno v:
Science. 149:1507-1509
Differential and density equilibrium centrifugation have established the presence of alpha-hydroxy acid oxidase in microbodies of the kidney of the rat. The enzyme has been demonstrated in cells of the distal convoluted tubule by a microscopic cytoch
Autor:
Bennet M. Allen
Publikováno v:
Science. 46:216-218