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Autor:
Yiai Tong, Niraj Trivedi, Danielle Howell, David J. Solecki, Jakub K. Famulski, Richard J. Gilbertson, Yuan Yang
Publikováno v:
Science. 330:1834-1838
Exiting the Birthplace In the developing mammalian brain, new neurons are not always born where they are needed. In order for immature neurons of the mouse cerebellum to leave their birthplace in the germinal zone and find their functional niche in t
Autor:
Robert J. Lefkowitz, Stephen J. Perry, Matthew K. Topham, Stephen M. Prescott, Debra S. Regier, Christopher D. Nelson
Publikováno v:
Science. 315:663-666
Seven-transmembrane receptor (7TMR) signaling is transduced by second messengers such as diacylglycerol (DAG) generated in response to the heterotrimeric guanine nucleotide–binding protein G q and is terminated by receptor desensitization and degra
Autor:
David Dornan, Angie Mah, Somasekar Seshagiri, Harumi Shimizu, Vishva M. Dixit, Karen O'Rourke, Tanay Dudhela, Michael Eby
Publikováno v:
Science. 313:1122-1126
The ataxia telangiectasia mutated (ATM) protein kinase is a critical component of a DNA-damage response network configured to maintain genomic integrity. The abundance of an essential downstream effecter of this pathway, the tumor suppressor protein
Autor:
Andrew, Yoon, Guang, Peng, Yves, Brandenburger, Yves, Brandenburg, Ornella, Zollo, Wei, Xu, Eduardo, Rego, Davide, Ruggero
Publikováno v:
Science. 312:902-906
The DKC1 gene encodes a pseudouridine synthase that modifies ribosomal RNA (rRNA). DKC1 is mutated in people with X-linked dyskeratosis congenita (X-DC), a disease characterized by bone marrow failure, skin abnormalities, and increased susceptibility
Publikováno v:
Science. 311:377-381
RhoA signaling plays a critical role in many cellular processes, including cell migration. Here we show that the vaccinia F11L protein interacts directly with RhoA, inhibiting its signaling by blocking the interaction with its downstream effectors Rh
Publikováno v:
Science. 309:1369-1373
We have explored the use of embryonic stem cells as an alternative to oocytes for reprogramming human somatic nuclei. Human embryonic stem (hES) cells were fused with human fibroblasts, resulting in hybrid cells that maintain a stable tetraploid DNA
Autor:
Hendrik C. Korswagen, Boudewijn M.T. Burgering, Lydia M. M. de Vries-Smits, Marieke A.G. Essers, Paulien E. Polderman, Nick Barker
Publikováno v:
Science, 308(5725), 1181-1184. AMER ASSOC ADVANCEMENT SCIENCE
β-Catenin is a multifunctional protein that mediates Wnt signaling by binding to members of the T cell factor (TCF) family of transcription factors. Here, we report an evolutionarily conserved interaction of β-catenin with FOXO transcription factor
Autor:
Larry A. Sklar, Eric R. Prossnitz, Chetana M. Revankar, Daniel F. Cimino, Jeffrey B. Arterburn
Publikováno v:
Science. 307:1625-1630
The steroid hormone estrogen regulates many functionally unrelated processes in numerous tissues. Although it is traditionally thought to control transcriptional activation through the classical nuclear estrogen receptors, it also initiates many rapi
Autor:
Janet K. Dale, Stephen Straus, Razqallah Hakem, Lixin Zheng, Helen C. Su, Nicolas Bidère, Alan Cubre, Leonardo Salmena, Keiko Sakai, Michael J. Lenardo
Publikováno v:
Science. 307:1465-1468
Caspase-8, a proapoptotic protease, has an essential role in lymphocyte activation and protective immunity. We show that caspase-8 deficiency (CED) in humans and mice specifically abolishes activation of the transcription factor nuclear factor kappaB
Autor:
Martina Vockerodt, Casper Paludan, Dieter Kube, Thomas Tuschl, Dorothee Schmid, Markus Landthaler, Christian Münz
Publikováno v:
Science. 307:593-596
CD4 + T cells classically recognize antigens that are endocytosed and processed in lysosomes for presentation on major histocompatibility complex (MHC) class II molecules. Here, endogenous Epstein-Barr virus nuclear antigen 1 (EBNA1) was found to gai