Zobrazeno 1 - 10
of 31
pro vyhledávání: ''
Autor:
Qiong Xia, Huimin Zhang, Jörg J. Goronzy, Timothy M. Gould, Jun Jin, Wenqiang Cao, Cornelia M. Weyand, Daniela Weiskopf, Alba Grifoni, Alessandro Sette, Chulwoo Kim, Xuanying Li
Publikováno v:
Sci Immunol
The nutrient-sensing mammalian target of rapamycin (mTOR) is integral to cell fate decisions after T cell activation. Sustained mTORC1 activity favors the generation of terminally differentiated effector T cells instead of follicular helper and memor
Autor:
Miao Sun, Eva Tolosa, Tessa M. Campbell, Sandra von Hardenberg, Joseph C. Sun, Rebecca A. Marsh, Frank Cichocki, Moneef Shoukier, Theodore T. Drashansky, Dorina Avram, Christine Tao, Yenan T. Bryceson, Tim D. Holmes, Eric Y. Helm, Heinrich Schlums, Cheng-Ying Wu, Yin C. Lin, Robert Månsson, Hongya Han, Samuel C. C. Chiang, Ram Vinay Pandey, Christian Klemann, Colleen M. Lau
Publikováno v:
Science Immunology. 6
Epigenetic landscapes can provide insight into regulation of gene expression and cellular diversity. Here, we examined the transcriptional and epigenetic profiles of seven human blood natural killer (NK) cell populations, including adaptive NK cells.
Autor:
Wenqi Wang, Praveen Krishna Veerasubramanian, Christian F. Guerrero-Juarez, Wendy Liu, Melissa B. Lodoen, Esther Y. Chen, Jessica Y. Hsieh, Maksim V. Plikus, David A. Fruman, Timothy L. Downing, Raji R. Nagalla, Kosuke Yamaga, Hamza Atcha, Vijaykumar S. Meli, Thuy U. Luu, William Pandori
Publikováno v:
Science advances, vol 6, iss 49
Science Advances
Science Advances
Macrophages sense biophysical cues in the microenvironment via YAP to tune their inflammatory response.
Macrophages are innate immune cells that adhere to the extracellular matrix within tissues. However, how matrix properties regulate their fun
Macrophages are innate immune cells that adhere to the extracellular matrix within tissues. However, how matrix properties regulate their fun
A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses
Autor:
Lisa Kleissl, Christoph Bock, Victoria Stary, Matthias Farlik, J. Strobl, Gottfried Fischer, Wolfgang Weninger, Ram Vinay Pandey, Patrick Starlinger, David Pereyra, Georg Stary
Publikováno v:
Science Immunology. 5
Adaptive features of natural killer (NK) cells have been reported in various species with different underlying mechanisms. It is unclear, however, which NK cell populations are capable of mounting antigen-specific recall responses and how such functi
Autor:
Yi-Ru Yu, Meng-Fen Wu, Caroline Arber, Navin Varadarajan, B.M. Carreres, Fatemeh Sadeghi, Melisa Martinez-Paniagua, David Gfeller, Malcolm K. Brenner, Elisabeth Hoyer, Michael Hebeisen, Jan A. Rath, Nazila Nouraee, Nathalie Rufer, Tao Wang, Gagan Bajwa, Isabelle Gruber, Ping-Chih Ho
Publikováno v:
Science advances, vol. 6, no. 27, pp. eaaz7809
Science Advances
Science Advances
TCR-CD8–engineered CD4+ T cells have potent antitumor activity with sustained expression of diverse transcriptional programs.
Transgenic coexpression of a class I–restricted tumor antigen–specific T cell receptor (TCR) and CD8αβ (TCR8) r
Transgenic coexpression of a class I–restricted tumor antigen–specific T cell receptor (TCR) and CD8αβ (TCR8) r
Autor:
Lauren E. Higdon, Jonathan S. Maltzman
Publikováno v:
Science Immunology. 5
Sestrin proteins dampen TCR signaling and induce antigen-independent natural killer-like cytotoxicity in highly differentiated CD8 T cells.
Autor:
Gan, Huoqun, Shen, Tian, Chupp, Daniel P., Taylor, Julia R., Sanchez, Helia N., Li, Xin, Xu, Zhenming, Zan, Hong, Casali, Paolo
Publikováno v:
Science Advances
Science advances, vol 6, iss 14
Science advances, vol 6, iss 14
Sirt1 mediates epigenetic modulation of B cell AID expression and antibody response by deacetylating histones, Dnmt1 and NF-κB p65.
Activation-induced cytidine deaminase (AID) mediates immunoglobulin class switch DNA recombination (CSR) and som
Activation-induced cytidine deaminase (AID) mediates immunoglobulin class switch DNA recombination (CSR) and som
Autor:
Fei Lin, Xuemei Du, Weining Weng, Qinghua Nie, Yang Li, Shiwei Wang, Qingyou Xia, Zhiqing Li, Yiqiang Wang, Jian Yan, Mingqiao Wang, Nan Wang, Yang-Rui Li, L. Ma, Xiquan Zhang, Qin Zhang, Sheng-Ce Tao, Ziqing Chen, Yuemeng Wang, Zhaohui Wang, Kenneth D. Poss, Xuefan Xu, Fulin Chen, Mira I. Pronobis, Dongliang Huang, Rong Pan, Meng Xun, Zhiqiang Wang, Susan Zheng, Hou Bing, Xiaodong Zhao, Ying Zhang, Kun Wang, Yu-Xian Zhu, Wenfang Zeng, Huaping Dai, Li Jiang, Ying Lin, Yuan Yu, Yanfang Tang, Jing Geng, Guangcun Cheng, Zheng Yuan
Publikováno v:
Science Advances
A massively parallel array of monoclonal antibodies enables rapid antibody development and target discovery across species.
Antibodies are essential for elucidating gene function. However, affordable technology for proteome-scale antibody genera
Antibodies are essential for elucidating gene function. However, affordable technology for proteome-scale antibody genera
Autor:
Uttiya Basu, Wanwei Zhang, Haiteng Deng, Brice Laffleur, Lekha Nair, Gerson Rothschild, Mingyan Fang, Yiyun Chen, Zhi-Ping Liu, Yuling Chen, Junghyun Lim, Pankaj Kumar Giri, Lennart Hammarström, Jiguang Wang
Publikováno v:
Sci Immunol
B cells undergo two types of genomic alterations to increase antibody diversity: introduction of point mutations into immunoglobulin heavy- and light-chain (IgH and IgL) variable regions by somatic hypermutation (SHM) and alteration of antibody effec
Autor:
Yuying Liu, Bo Huang, Xiaoyu Liang, Xiaohui Zhang, Ke Tang, Yabo Zhou, Nannan Zhou, Tianzhen Zhang, Yunfeng Gao, Zhen Zhang, Yu Hu, Jiadi Lv, Quanli Gao, Zhenfeng Wang, Xinfeng Chen, Mengyu Liu, Feiran Cheng, Yiliang Fang, Jing Xie, Yi Zhang
Publikováno v:
Science Immunology. 5
Cytokine release syndrome (CRS) counteracts the effectiveness of chimeric antigen receptor (CAR) T cell therapy in cancer patients, but the mechanism underlying CRS remains unclear. Here, we show that tumor cell pyroptosis triggers CRS during CAR T c