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Autor:
Jonathan B. Mitchem, Esther Lu, Andrea Wang-Gillam, Haeseong Park, Steven C. Hunt, Matthew L. Silviera, Shahed N. Badiyan, Olivia Aranha, Ebunoluwa E. Otegbeye, Benjamin R. Tan, Kian-Huat Lim, Lauren E. Henke, Hyun Jik Kim, Manik Amin, Nikolaos A. Trikalinos, Rama Suresh, Paul E. Wise, Katrina S. Pedersen, Matthew G. Mutch, Matthew A. Ciorba
Publikováno v:
Cancer Research. 80:CT234-CT234
Background: Epacadostat is an orally active, potent and selective inhibitor of indoleamine 2, 3-dioxygenase 1 (IDO1). IDO1 inhibition enhances cytotoxic T cell activation by dendritic cells, and significantly decreases regulatory T cell proliferation