Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Raymond Rothstein"'
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Marker genes for the monocyte-macrophage-DC subpopulations identified in Supplementary Figure 5H. Only genes with adjusted p-value < 0.01 and average log fold-change > 0.3 were included. gene, gene name; p_val, p-value calculated based on Wilcoxon te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::318ab2f876a4f6d65d1cc34e89e50b21
https://doi.org/10.1158/2159-8290.22540394
https://doi.org/10.1158/2159-8290.22540394
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Pharmacodynamics of STAT3 ASO in CT26 STK11 KO model. (A) Percentage of CD45+ immune cells among live cells from untreated or drug-treated STK11 KO CT26 tumors as indicated. (B) Percentage of Ly6G+ granulocytic cells among live CD45+ cells. (C) Perce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97c1f0437b345d54961ba0824610dcb6
https://doi.org/10.1158/2159-8290.22540439.v1
https://doi.org/10.1158/2159-8290.22540439.v1
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Characterization of CT26 tumor cell lines with CRISPR-mediated STK11 loss. (A) Western blotting of STK11, phosphorylated AMPK (p-AMPK), total AMPK, and actin in lysates from wild-type CT26 cells (CT26 WT), STK11 CRISPR knock-out clones 26C16, 26C10 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e9abd313267d20ec8be5a20f91e500
https://doi.org/10.1158/2159-8290.22540424
https://doi.org/10.1158/2159-8290.22540424
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Characterization of STAT3 phosphorylation in the CT26 STK11 KO model and from primary human NSCLC tumors. (A) Representative multispectral fluorescence imaging of phosphorylated murine STAT3 (pSTAT3), CD45, CD163, and nuclei (DAPI), as indicated, wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1510469c1301fd2af437c5503ecf895b
https://doi.org/10.1158/2159-8290.22540415
https://doi.org/10.1158/2159-8290.22540415
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Marker genes for the main CD45+ cell populations identified in Supplementary Figure 5. Only genes with adjusted p-value < 0.01 and average log fold-change > 0.3 were included. gene, gene name; p_val, p-value calculated based on Wilcoxon test; avg_log
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2b22d3c600a7b9c918b8637d6e83d0
https://doi.org/10.1158/2159-8290.22540397
https://doi.org/10.1158/2159-8290.22540397
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
CPI efficacy in EMT6 STK11wt, KO, and KO/KI tumors. (A) Western blotting of STK11, phosphorylated AMPK (p-AMPK), total AMPK, and actin in lysates from wild-type EMT6 cells (EMT6 WT), STK11 CRISPR KO clone (EMT6 KO) and from STK11 KO clone engineered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54fc72bab8bfb89a0fb25c10893683aa
https://doi.org/10.1158/2159-8290.22540409
https://doi.org/10.1158/2159-8290.22540409
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Suppressive activity of MDSCs isolated from CT26 WT or CT26 SKT11 KO tumors and pharmacological reversal by STAT3 ASO treatment in the CT26 WT model. (A) Percentage of naive T cell proliferation by anti-CD3/CD28/IL2 stimulation in the presence of Gr1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d6eea99ce3b3347f624111cb1500fcf
https://doi.org/10.1158/2159-8290.22540436.v1
https://doi.org/10.1158/2159-8290.22540436.v1
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Marker genes for the lymphocyte subpopulations identified in Supplementary Figure 6. Only genes with adjusted p-value < 0.01 and average log fold-change > 0.3 were included. gene, gene name; p_val, p-value calculated based on Wilcoxon test; avg_logFC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2474ffb63ac77577a7c49fb13c74f811
https://doi.org/10.1158/2159-8290.22540391
https://doi.org/10.1158/2159-8290.22540391
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
Association between STK11 and KRAS mutation and immunotherapy response. In STK11mut/KRASmut NSCLC, poor response to durvalumab (A) and durvalumab + tremelimumab (B) is mainly driven by STK11 mutation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2de33550b6b9604a3aba3f369dfc0887
https://doi.org/10.1158/2159-8290.22540448
https://doi.org/10.1158/2159-8290.22540448
Autor:
Michael D. Oberst, Maria Libera Ascierto, Phillip A. Dennis, J. Carl Barrett, Melanie M. Frigault, Rajiv Raja, Shaad E. Abdullah, Ashok Gupta, Ronald Herbst, Ricardo J. Miragaia, Theresa A. Proia, Ina Bisha, Matthew Griffin, John Meekin, Philip Martin, Stephen Blackmore, Kathy Mulgrew, Raymond Rothstein, Rebecca Halpin, Yashaswi Shrestha, Melissa de los Reyes, Maria Jure-Kunkel, Nathan Standifer, Song Wu, Nabendu Pore
List of genes differentially expressed in STK11mut vs STK11wt tumors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10e7aea352d5213b943b0ef676fbdc30
https://doi.org/10.1158/2159-8290.22540403
https://doi.org/10.1158/2159-8290.22540403