Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Lorenzo Trippa"'
Autor:
Rifaquat Rahman, Steffen Ventz, Robert Redd, Timothy Cloughesy, Brian M. Alexander, Patrick Y. Wen, Lorenzo Trippa
Publikováno v:
Clinical Cancer Research. :OF1-OF5
Drug development can be associated with slow timelines, particularly for rare or difficult-to-treat solid tumors such as glioblastoma. The use of external data in the design and analysis of trials has attracted significant interest because it has the
Autor:
Ian E. Krop, Eric P. Winer, Franziska Michor, Kornelia Polyak, Tari A. King, Leila Russo, Patrizia Dell'Orto, Aditya Bardia, Michelle K. DeMeo, Eileen Wrabel, Adrienne G. Waks, Laura M. Spring, Carlos L. Arteaga, Vandana G. Abramson, Ingrid A. Mayer, Denise A. Yardley, Lorenzo Trippa, Shayna Stein, Giuseppe Viale, Otto Metzger Filho
Pattern of HER2 amplification in the subset of HER2 heterogeneous tumors. Heatmap generated using data from central pathology evaluation of HER2 heterogeneity. The graphic includes patients classified as HER2 heterogeneous depicted in each row. The c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e8aedc7b8facd30ae5fdfd8dec38a2a
https://doi.org/10.1158/2159-8290.22538948
https://doi.org/10.1158/2159-8290.22538948
Autor:
Ian E. Krop, Eric P. Winer, Franziska Michor, Kornelia Polyak, Tari A. King, Leila Russo, Patrizia Dell'Orto, Aditya Bardia, Michelle K. DeMeo, Eileen Wrabel, Adrienne G. Waks, Laura M. Spring, Carlos L. Arteaga, Vandana G. Abramson, Ingrid A. Mayer, Denise A. Yardley, Lorenzo Trippa, Shayna Stein, Giuseppe Viale, Otto Metzger Filho
FISH raw counts
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70029c4a13c0e215d7eb9c8e6691c2bd
https://doi.org/10.1158/2159-8290.22538927
https://doi.org/10.1158/2159-8290.22538927
Autor:
Ian E. Krop, Eric P. Winer, Franziska Michor, Kornelia Polyak, Tari A. King, Leila Russo, Patrizia Dell'Orto, Aditya Bardia, Michelle K. DeMeo, Eileen Wrabel, Adrienne G. Waks, Laura M. Spring, Carlos L. Arteaga, Vandana G. Abramson, Ingrid A. Mayer, Denise A. Yardley, Lorenzo Trippa, Shayna Stein, Giuseppe Viale, Otto Metzger Filho
Relationship between ERBB2 copy number and pCR. A, Median HER2/CEP17 ratio for the overall population acording to pCR results. P-value is from a Wilcoxon test. B, Median HER2/CEP17 ratio for the hormone receptor-positive and hormone receptor-negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd62d9fd6c7b92802655394139d4fd53
https://doi.org/10.1158/2159-8290.22538939.v1
https://doi.org/10.1158/2159-8290.22538939.v1
Autor:
Ian E. Krop, Eric P. Winer, Franziska Michor, Kornelia Polyak, Tari A. King, Leila Russo, Patrizia Dell'Orto, Aditya Bardia, Michelle K. DeMeo, Eileen Wrabel, Adrienne G. Waks, Laura M. Spring, Carlos L. Arteaga, Vandana G. Abramson, Ingrid A. Mayer, Denise A. Yardley, Lorenzo Trippa, Shayna Stein, Giuseppe Viale, Otto Metzger Filho
Logistic Regression Results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::074fb2c8075bb594672144da7a119467
https://doi.org/10.1158/2159-8290.22538921
https://doi.org/10.1158/2159-8290.22538921
Autor:
Ian E. Krop, Eric P. Winer, Franziska Michor, Kornelia Polyak, Tari A. King, Leila Russo, Patrizia Dell'Orto, Aditya Bardia, Michelle K. DeMeo, Eileen Wrabel, Adrienne G. Waks, Laura M. Spring, Carlos L. Arteaga, Vandana G. Abramson, Ingrid A. Mayer, Denise A. Yardley, Lorenzo Trippa, Shayna Stein, Giuseppe Viale, Otto Metzger Filho
List of all AEs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::127ba422f8b0e36f003c8109fd0b9c37
https://doi.org/10.1158/2159-8290.22538930
https://doi.org/10.1158/2159-8290.22538930
Autor:
Ian E. Krop, Eric P. Winer, Franziska Michor, Kornelia Polyak, Tari A. King, Leila Russo, Patrizia Dell'Orto, Aditya Bardia, Michelle K. DeMeo, Eileen Wrabel, Adrienne G. Waks, Laura M. Spring, Carlos L. Arteaga, Vandana G. Abramson, Ingrid A. Mayer, Denise A. Yardley, Lorenzo Trippa, Shayna Stein, Giuseppe Viale, Otto Metzger Filho
Assessment of spatial HER2 heterogeneity. A, The maximum area fraction of HER2 non-amplified cells in each patient. P-value is from a Wilcoxon test. The lower and upper hinges correspond to the 1st and 3rd quartiles, respectively. The lower and upper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18751211319f23c7f1eb40a16bc289ce
https://doi.org/10.1158/2159-8290.22538942.v1
https://doi.org/10.1158/2159-8290.22538942.v1
Autor:
Ian E. Krop, Eric P. Winer, Franziska Michor, Kornelia Polyak, Tari A. King, Leila Russo, Patrizia Dell'Orto, Aditya Bardia, Michelle K. DeMeo, Eileen Wrabel, Adrienne G. Waks, Laura M. Spring, Carlos L. Arteaga, Vandana G. Abramson, Ingrid A. Mayer, Denise A. Yardley, Lorenzo Trippa, Shayna Stein, Giuseppe Viale, Otto Metzger Filho
Intratumor heterogeneity is postulated to cause therapeutic resistance. To prospectively assess the impact of HER2 (ERBB2) heterogeneity on response to HER2-targeted therapy, we treated 164 patients with centrally confirmed HER2-positive early-stage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a398926894d3f2961bea956ef7d118f7
https://doi.org/10.1158/2159-8290.c.6548945
https://doi.org/10.1158/2159-8290.c.6548945
Autor:
Ian E. Krop, Eric P. Winer, Franziska Michor, Kornelia Polyak, Tari A. King, Leila Russo, Patrizia Dell'Orto, Aditya Bardia, Michelle K. DeMeo, Eileen Wrabel, Adrienne G. Waks, Laura M. Spring, Carlos L. Arteaga, Vandana G. Abramson, Ingrid A. Mayer, Denise A. Yardley, Lorenzo Trippa, Shayna Stein, Giuseppe Viale, Otto Metzger Filho
Logistic regression model calibration. A, Model 1. B, Model 2. C, Model 3. D, Model 4. E, Model 5. F, Model 6. G, Model 7. A-G, Calibration curves with summary statistics. Dxy is the Somer's rank correlation between the predicted and observed values;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e3ff10ff45ded0e6302af101742e0e
https://doi.org/10.1158/2159-8290.22538933
https://doi.org/10.1158/2159-8290.22538933
Autor:
Ian E. Krop, Eric P. Winer, Franziska Michor, Kornelia Polyak, Tari A. King, Leila Russo, Patrizia Dell'Orto, Aditya Bardia, Michelle K. DeMeo, Eileen Wrabel, Adrienne G. Waks, Laura M. Spring, Carlos L. Arteaga, Vandana G. Abramson, Ingrid A. Mayer, Denise A. Yardley, Lorenzo Trippa, Shayna Stein, Giuseppe Viale, Otto Metzger Filho
Predicting pathological complete response (pCR) from single cell HER2 FISH and clinical data. A, Receiver operating characteristic (ROC) curves for the prediction models using the frequency of HER2 unamplified cells to predict pathological response.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d0e8d5e6f840cd0d0c411eef9b7f9d
https://doi.org/10.1158/2159-8290.22538936
https://doi.org/10.1158/2159-8290.22538936