Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kristina Xega"'
Autor:
Kristina Xega, Xingyue He, Neeraja Idamakanti, Mithun Khattar, Stephen Grossman, Keli Song, Dennis Huszar
Publikováno v:
Cancer Research. 79:3252-3252
SUMOylation is a reversible post-translational modification that regulates protein function by covalent attachment of the small ubiquitin-like modifier (SUMO) protein to protein substrates. TAK-981 is a novel, selective small molecule inhibitor of th
Autor:
Kristina Xega, Michael Milhollen, Dennis Huszar, Erik Koenig, Eric S. Lightcap, Vaishali Shinde, Stephen Grossman, Keli Song, Sharon Friedlander, Omid Ghasemi, Allison Berger, Pooja Shah, Gary Shapiro, Agatha Zawadzka
Publikováno v:
Cancer Research. 79:3079-3079
TAK-981 is a small molecule inhibitor of the SUMOylation enzyme cascade which is currently in a Phase I clinical trial (NCT03648372). TAK-981 selectively inhibits the activity of the SUMO activating enzyme, forming a covalent adduct between TAK-981 a
Autor:
Johara Chouitar, Dennis Huszar, Allison Berger, Katherine Galvin, Vaishali Shinde, Aimy Tse, Keli Song, Omid Ghasemi, Agatha Zawadzka, Patrick J. LeRoy, Kristina Xega, Evan Luongo, Xingyue He, Michelle Ganno-Sherwood, Stephan Grossman, Cierra Casson
Publikováno v:
Cancer Research. 79:LB-319
Mouse syngeneic tumor models play a crucial role in the translationally oriented process of assessing the preclinical activity and mechanism of action of emerging novel immunotherapies and immunotherapy combinations. Recent advancements in fluorescen
Autor:
Mohammad Shahid, Miguel Rivera, Shyamala Maheswaran, Nabeel Bardeesy, David T. Miyamoto, Mehmet Toner, Daniel A. Haber, David T. Ting, Sridhar Ramaswamy, Ravi Kapur, Ben S. Wittner, Jordan C. Ciciliano, Toshi Shioda, Brian W. Brannigan, Haley Ellis, Olivia C. MacKenzie, Kristina Xega, Ajay Shah, Julie Trautwein, Na Qu
Publikováno v:
Cancer Research. 74:NG04-NG04
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal adult malignancy due to the propensity of this disease to metastasize. Circulating tumor cells (CTCs) are thought to be enriched for cells with metastatic potential and their character
Autor:
Daniel A. Haber, Matteo Ligorio, Kristina Xega, Laura Indolfi, Robert Langer, Nicola Aceto, Francesca Bersani, Jeffrey W. Clark, Cristina R. Ferrone, Elazer R. Edelman, David T. Ting
Publikováno v:
Cancer Research. 74:4584-4584
INTRODUCTION. The majority of patients with pancreatic ductal adenocarcinoma (PDAC) succumb to the disease within 12-24 months from their diagnosis mainly due to the intrinsic chemorefractory behavior of this cancer. Chemoresistance is a multifactori