Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Jae J. Song"'
Publikováno v:
Clinical Cancer Research. 11:7607-7613
Purpose and Experimental Design: Previously, we observed that the activation of p38 mitogen-activated protein kinase (MAPK) and c-Jun NH2-terminal kinase (JNK1) is mediated through the activation of apoptosis signal–regulating kinase 1 (ASK1) as a
Publikováno v:
Cancer Immunology Research. 5:B81-B81
As combining therapeutic agents with different action mechanisms may enhance efficacy, YSC-02, an oncolytic adenovirus with multi targets was loaded with five different genes, which were designed with the expectation that different action mechanisms
Autor:
Dongxu Kang, Hye Jin Choi, Eun Kyung Kim, So Y. Kim, Seungha Lee, Jae J. Song, Sujin Kang, Joo Hang Kim
Publikováno v:
Cancer Research. 74:694-694
Gemcitabine as the standard chemotherapy agent to pancreatic cancer has proved effective; however, the response rate remains at 5.4% and the 5-year survival rate is extremely poor. Due to the shortcomings of gemcitabine and the presence of gemcitabin
Publikováno v:
Molecular Cancer Therapeutics. 12:C237-C237
Although the combination of gemcitabine with a variety of cytotoxic and targeted agents has generally shown no significant survival advantage as compared with gemcitabine alone, still, many targeted agents against various pathways remain to be tested
Publikováno v:
Cancer Research. 73:2957-2957
TRAIL-induced activation of Akt catalytic activity and phosphorylation were highly correlated with p38/HSP27 phosphorylation, whereas the phosphorylation of p38/HSP27 increased further during incubation with curcumin and TRAIL, which caused significa
Publikováno v:
Cancer Research. 72:2273-2273
Curcumin as an anticancer agent was investigated to study how it can regulate cancer cells’ destination to either apoptosis or autophagy. At higher concentration, curcumin induced ROS production leading to JNK and p38 phosphorylation in DU-145 pros
Autor:
So Y. Kim, Joo Hang Kim, Wungki Park, Jae J. Song, Jina Kim, Hyo R. Yoon, Kijae Hong, Hye Jin Choi, Seeun Oh, Sujin Kang
Publikováno v:
Cancer Research. 71:C42-C42
Previously, we have shown that p38-HSP27 acted as modulators from survival to death depending on the apoptotic strength in prostate cancer cells. For example, if the apoptotic strength is in the moderate range, p38-HSP27 acted to increase Akt catalyt
Publikováno v:
Cancer Research. 71:4104-4104
Previously, we demonstrated that TRAIL-induced p38 activation was responsible for the increases of Akt catalytic and invasive activity. Interestingly, TRAIL induced dramatically Akt catalytic activation in TRAIL-sensitive cells, whereas TRAIL did not
Autor:
Jae J. Song, Joo Hang Kim, So Y. Kim, Hoan N. Nguyen, Hyo R. Yoon, Seeun Oh, Bo K. Sun, Hye Jin Choi
Publikováno v:
Cancer Research. 71:4107-4107
The effect of combination of TRAIL and curcumin enhanced apoptotic cell death in many other studies. However, the exact molecular mechanism of enhanced apoptotic cell death by TRAIL plus curcumin was not yet completely understood. In this study, we c
Autor:
Yong J. Lee, Joo Hang Kim, Hye Jin Choi, Bo K. Sun, So Y. Kim, Joohyuk Sohn, Seeun Oh, Jae J. Song
Publikováno v:
Cancer Research. 70:1276-1276
In this paper, we demonstrate that TRAIL-induced p38 activation is responsible for the increases of Akt catalytic activity and invasive activity. For the confirmation of increases of Akt catalytic and invasive activity induced by TRAIL-induced p38 ac