Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Geethu E. Thomas"'
Autor:
Neil MacLean, Elias Orouji, Kerstin B. Kaufmann, Rose Hurren, Mark D. Minden, Aaron Botham, Veronique Voisin, Grace Egan, Geethu E. Thomas, Boaz Nachmias, Rashim Pal Singh, John E. Dick, Marcela Gronda, Jordan Chin, Dilshad H. Khan, Gary D. Bader, Laura Gracia Prat, Aaron D. Schimmer, Andrea Arruda, Xiaoming Wang
Publikováno v:
Cancer Research. 81:3099-3099
Mitochondrial metabolites affect epigenetic marks, but it is largely unknown whether mitochondrial metabolic enzymes can directly localize to the nucleus to regulate stem cell function in AML. Here, we discovered that the mitochondrial enzyme, Hexoki
Abstract 3098: Leukemia stem cells demonstrate enhanced DNA damage repair and chemoresistance in AML
Autor:
Neil MacLean, Parasvi S. Patel, Razq Hakem, Grace Egan, Aaron D. Schimmer, Rose Hurren, Veronique Voisin, Geethu E. Thomas
Publikováno v:
Cancer Research. 81:3098-3098
Leukemia stem cells demonstrate enhanced DNA damage repair and chemoresistance in AML Relapse of acute myeloid leukemia (AML) is common and the main cause of mortality in this disease. Leukemia stem cells (LSCs) contribute to relapse however the mech
Autor:
Aaron D. Schimmer, Jordan Chin, Razq Hakem, Grace Egan, Aaron Botham, Parasvi S. Patel, Geethu E. Thomas, Rose Hurren, Neil MacLean
Publikováno v:
Cancer Research. 80:3784-3784
Leukemia stem cells are responsible for the initiation and recurrence of AML. Cell differentiation requires the coordination of metabolic state and gene expression programs. It is known that metabolic intermediates can serve as cofactors in epigeneti
Autor:
Troy Ketela, Karen Arevalo, Aaron D. Schimmer, Moustafa Abohawya, Xiaoming Wang, Zachary Blatman, Rima Al-awar, Rose Hurren, Neil MacLean, Taira Kiyota, Geethu E. Thomas, Samir H. Barghout, Ahmed Aman
Publikováno v:
Cancer Research. 80:6321-6321
TAK-243 (MLN7243) is a first-in-class inhibitor of the ubiquitin-activating enzyme (UBA1) that catalyzes the first step in the ubiquitylation cascade whereby proteins are tagged with mono- or poly-ubiquitin to induce their degradation or modify their
Autor:
Mingjing Xu, Ayesh Seneviratne, Val A. Fajardo, Geethu E. Thomas, G. Wei Xu, Rose Hurren, S. Kim, Neil MacLean, Xiaoming Wang, Marcela Gronda, Danny Jeyaraju, Yulia Jitkova, David Sharon, Ahmed Aman, Rima Al-awar, Steven Chan, Mark D. Minden, Paul LeBlanc, Aaron D. Schimmer
Publikováno v:
Cancer Research. 79:3003-3003
Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by the accumulation of malignant myeloid cells that have arrested maturation. Most therapeutic regimens approved or under development are cytotoxics. An alternate, but less expl