Zobrazeno 1 - 10
of 9 107
pro vyhledávání: '"0301 basic medicine"'
Publikováno v:
Cancer Research. 81:3621-3634
Although the 14-3-3σ gene was initially identified as a p53 target gene in colorectal cancer cells, its potential role in intestinal tumorigenesis has remained unknown. Here we determined that 14-3-3σ expression is significantly downregulated in pr
Publikováno v:
Clinical Cancer Research. 27:3499-3502
[][1] Breast cancer continues to register one of the most common incidence and deaths among female cancers. However, during the last three decades, breast cancer treatment benefited from a sea-change for specific subtypes. These successes led to incr
Autor:
Xinyi Liao, Ziwen Li, Yameng Hu, Ruyuan Yu, Xingui Wu, Shuang Mo, Libing Song, Geyan Wu, Miaoling Tang, Meisongzhu Yang, Shuxia Zhang, Yingru Xu, Jun Li
Publikováno v:
Cancer Research. 81:3835-3848
Mitochondrial dynamics play vital roles in the tumorigenicity and malignancy of various types of cancers by promoting the tumor-initiating potential of cancer cells, suggesting that targeting crucial factors that drive mitochondrial dynamics may lead
Autor:
Ajay Prakash, Hee Sun Choi, Richard B. Hayes, Huilin Li, Jiyoung Ahn, Emilia N. Cobbs, Brandilyn A. Peters, Dia B. Beggs
Publikováno v:
Cancer Epidemiol Biomarkers Prev
Background: Increasing evidence suggests that tobacco smoking, a well-known driver of carcinogenesis, influences the gut microbiome; however, these relationships remain understudied in diverse populations. Thus, we performed an analysis of smoking an
Autor:
Rebecca L. Siegel, Priti Bandi, Stacey A. Fedewa, Nigar Nargis, Farhad Islami, Ahmedin Jemal, Adair K. Minihan
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 30:1287-1299
Cancer prevention and early detection efforts are central to reducing cancer burden. Herein, we present estimates of cancer risk factors and screening tests in 2018 and 2019 among US adults, with a focus on smoking cessation. Cigarette smoking reache
Autor:
Bo Xu, Rui Ma, Kun-Yu Teng, Melissa Yu, Michael A. Caligiuri, Ting Lu, Jianhua Yu, Lei Tian, Zhenlong Li, Shoubao Ma, Yong Peng, Anthony Mansour, Jianying Zhang, Tasha Barr
Publikováno v:
Cancer Res
IL15 is a pleiotropic cytokine with multiple roles that improve immune responses to tumor cells. Oncolytic viruses (OV) specifically lyse tumors and activate immune responses. Systemic administration of IL15 or its complex with the IL15Rα and chimer
Publikováno v:
Molecular Cancer Therapeutics. 20:1305-1315
Glioblastoma (GBM), as the immunologically cold tumor, respond poorly to programmed cell death 1 (PD-1) immune checkpoint inhibitors because of insufficient immune infiltration. Herein, through the analysis of The Cancer Genome Atlas data and clinica
Autor:
Kamal Mandal, Jeffrey D. Whitman, Kevin R. Parker, Elliot Stieglitz, Faranak Fattahi, Aashish Manglik, Jonathan Ramirez, Veronica Steri, Yu-Hsiu T. Lin, Ansuman T. Satpathy, Anne Deucher, Makeba Marcoulis, Matthew A. Nix, Huimin Geng, Paul Phojanokong, Arun P. Wiita, Sagar P. Bapat, Byron Hann, Kristie L. White, Neha Paranjape, Jose M. Rivera
Publikováno v:
Cancer Discovery. 11:2032-2049
Alternative strategies are needed for patients with B-cell malignancy relapsing after CD19-targeted immunotherapy. Here, cell surface proteomics revealed CD72 as an optimal target for poor-prognosis KMT2A/MLL1-rearranged (MLLr) B-cell acute lymphobla
Autor:
Matteo Costacurta, Edwin D. Hawkins, Ricky W. Johnstone, Grant A. McArthur, Jane Oliaro, Paul J Neeson, Paul A. Beavis, Stephin J. Vervoort, Joe Jiang Zhu, Deborah Meyran, Conor J. Kearney, Emily J. Lelliott, Ian A. Parish, Pilar M. Dominguez, Laura Kirby, Nicole M. Haynes, Lydia Lim, Luciano G. Martelotto, Kelly M Ramsbottom, Magnus Zethoven, Isabella Y. Kong, Karen E. Sheppard, Jarrod J. Sandow, Izabela Todorovski
Publikováno v:
Cancer Discovery. 11:2582-2601
Pharmacologic inhibitors of cyclin-dependent kinases 4 and 6 (CDK4/6) are an approved treatment for hormone receptor–positive breast cancer and are currently under evaluation across hundreds of clinical trials for other cancer types. The clinical s
Autor:
Sara Zanivan, Rafael S. Martinez, William C. Clark, Paul Peixoto, Sergio Lilla, Colin Nixon, Laura C. A. Galbraith, Eric Hervouet, Ladan Fazli, Ann Hedley, Sonia H.Y. Kung, Luke Gaughan, Linda K. Rushworth, Hing Y. Leung, Martin E. Gleave, Gillian M. Mackay, Chara Ntala, Mark Salji, David Sumpton, Arnaud Blomme, Giovanny Rodriguez Blanco, Elodie Renaude
Publikováno v:
Cancer Research. 81:3664-3678
Androgen deprivation therapy (ADT) is the standard of care for treatment of nonresectable prostate cancer. Despite high treatment efficiency, most patients ultimately develop lethal castration-resistant prostate cancer (CRPC). In this study, we perfo