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Autor:
Huifen Zhou, Songhui Xu, Cancan Zhang, Qixin Leng, Hao-Wu Jiang, Jiaxi He, Donge Tang, Xin-Yan Geng, De-Xue Fu, Yong Dai, Rui Sun
Publikováno v:
Cancer Research. :OF1-OF15
The histone demethylase KDM6A controls gene expression by the epigenetic regulation of H3K27 methylation and functions in diverse processes, including differentiation, development, and cancer. Here, we investigated the role of KDM6A in prostate cance
Autor:
Xiaodong Shu, Shan Cheng, Jianhong Xia, Duanqing Pei, Qiuling Huang, Xiaofei Zhang, Haiyun Wang
Publikováno v:
Molecular Cancer Research. 20:253-264
Dysregulation of Notch signaling has been implicated in cellular transformation and tumorigenesis in a variety of cancers while potential roles of MIB1, an E3 ubiquitin ligase required for efficient Notch activation, remains to be investigated. We an
Autor:
Yavuz T Durmaz, Amin H Sabet, Deli Hong, Anna C. Schinzel, Emily Walton, Kristen L Jones, Maura Sticco-Ivins, Yixiang Li, Quang-Dé Nguyen, Roderick T. Bronson, Sabina Signoretti, Tran C. Thai, Erik H. Knelson, David A. Barbie, Amir Vajdi, Matthew G. Oser, Wenhua Gao, Michael Y. Tolstorukov, Marina Vivero
Publikováno v:
Cancer Res
Neuroendocrine to nonneuroendocrine plasticity supports small cell lung cancer (SCLC) tumorigenesis and promotes immunogenicity. Approximately 20% to 25% of SCLCs harbor loss-of-function (LOF) NOTCH mutations. Previous studies demonstrated that NOTCH
Autor:
Emanuela Ercolano, Bora Agit, Emmanuel Atangana Maze, David A Hilton, Sylwia Ammoun, Shona Reeves, Robert D Belshaw, Kathreena M Kurian, C. Oliver Hanemann, David Parkinson, Liyam Laraba
Publikováno v:
Cancer Research. 82:235-247
Deficiency of the tumor suppressor Merlin causes development of schwannoma, meningioma, and ependymoma tumors, which can occur spontaneously or in the hereditary disease neurofibromatosis type 2 (NF2). Merlin mutations are also relevant in a variety
Autor:
Emmy W. Verschuren, Pekka Paivinen, Sushil Tripathi, Ashwini S. Nagaraj, Eva Domenech-Moreno, Tomi P. Mäkelä, Kari Vaahtomeri, Iris P. L. Wong, Sarang S. Talwelkar, Marc Foretz, Benoit Viollet, Yan Yan, Yajing Gao
Publikováno v:
Clinical Cancer Research
Clinical Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, American Association for Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, American Association for Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Purpose: Mutations in STK11 (LKB1) occur in 17% of lung adenocarcinoma (LUAD) and drive a suppressive (cold) tumor immune microenvironment (TIME) and resistance to immunotherapy. The mechanisms underpinning the establishment and maintenance of a cold
Autor:
Crissandra Piper, Matthew D. Hall, Marta Kulis, Richard L. Bennett, Alok Swaroop, Min Shen, Richard B. Lock, Jonathan H. Shrimp, Jon A. Oyer, Christine Will, Alberto Riva, Heidi L. Casellas Roman, Duohui Jing, Jianping Li, Catalina Troche, Adolfo A. Ferrando, Jacob S. Roth, Daphné Dupéré-Richer, Jonathan D. Licht, Julia Cathryn Hlavka-Zhang
Publikováno v:
Cancer Discovery. 12:186-203
Mutations in epigenetic regulators are common in relapsed pediatric acute lymphoblastic leukemia (ALL). Here, we uncovered the mechanism underlying the relapse of ALL driven by an activating mutation of the NSD2 histone methyltransferase (p.E1099K).
Publikováno v:
Molecular Cancer Research. 20:3-10
Centromere dysfunctions leading to numerical chromosome alterations are believed to be closely related to human cancers. As a centromere-specific protein, centromere protein A (CENP-A) replaces the histone H3 in centromeres and is therefore considere
Autor:
Joanne Xiu, Michael J. Pishvaian, Ari M. Vanderwalde, Jia Zeng, Yasmine Baca, Sunnie S. Kim, John L. Marshall, W. Michael Korn, Anthony F. Shields, Axel Grothey, Heinz-Josef Lenz, Philip A. Philip, Mohamed E. Salem, Jimmy J. Hwang, Richard M. Goldberg, Michael Cerniglia
Publikováno v:
Mol Cancer Ther
The prevalence of homologous recombination–DNA damage response (HR-DDR) genetic alterations is of therapeutic interest in gastroesophageal cancers. This study is a comprehensive assessment of HR-DDR mutation prevalence across gastroesophageal adeno
Autor:
Purna Chaitanya Konduri, Jung-whan Kim, Parinaz Sadat Alemi, Chantal Vidal, Adnin Ashrafi, Nivesh Jain, Sanchareeka Dey, Narges Salamat, Li Zhang, Sarada Preeta Kalainayakan, Poorva Ghosh
Publikováno v:
Molecular Cancer Research. 20:139-149
Lung adenocarcinoma (ADC) and squamous cell carcinoma (SCC) are two most common subtypes of lung cancer. Here, to identify new, targetable molecular properties of both subtypes, we monitored changes in the levels of heme- and oxidative phosphorylatio
Publikováno v:
Molecular Cancer Research. 20:30-44
Kirsten Rat Sarcoma (KRAS) gene somatic point mutations is one of the most prominently mutated proto-oncogenes known to date, and accounts for approximately 60% of all colorectal cancer cases. One of the most exciting drug development areas against c