Zobrazeno 1 - 10
of 12 818
pro vyhledávání: '"medicine"'
Autor:
Emmy W. Verschuren, Pekka Paivinen, Sushil Tripathi, Ashwini S. Nagaraj, Eva Domenech-Moreno, Tomi P. Mäkelä, Kari Vaahtomeri, Iris P. L. Wong, Sarang S. Talwelkar, Marc Foretz, Benoit Viollet, Yan Yan, Yajing Gao
Publikováno v:
Clinical Cancer Research
Clinical Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, American Association for Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Clinical Cancer Research, American Association for Cancer Research, 2021, pp.clincanres.2049.2021. ⟨10.1158/1078-0432.CCR-21-2049⟩
Purpose: Mutations in STK11 (LKB1) occur in 17% of lung adenocarcinoma (LUAD) and drive a suppressive (cold) tumor immune microenvironment (TIME) and resistance to immunotherapy. The mechanisms underpinning the establishment and maintenance of a cold
Autor:
Joanne Xiu, Michael J. Pishvaian, Ari M. Vanderwalde, Jia Zeng, Yasmine Baca, Sunnie S. Kim, John L. Marshall, W. Michael Korn, Anthony F. Shields, Axel Grothey, Heinz-Josef Lenz, Philip A. Philip, Mohamed E. Salem, Jimmy J. Hwang, Richard M. Goldberg, Michael Cerniglia
Publikováno v:
Mol Cancer Ther
The prevalence of homologous recombination–DNA damage response (HR-DDR) genetic alterations is of therapeutic interest in gastroesophageal cancers. This study is a comprehensive assessment of HR-DDR mutation prevalence across gastroesophageal adeno
Publikováno v:
Molecular Cancer Research. 20:30-44
Kirsten Rat Sarcoma (KRAS) gene somatic point mutations is one of the most prominently mutated proto-oncogenes known to date, and accounts for approximately 60% of all colorectal cancer cases. One of the most exciting drug development areas against c
Autor:
Xuemei Zhu, Joseph K. Lim, Melinda L. Irwin, Brenda Y. Hernandez, Herbert Yu, Xiaomei Ma, Harvey A. Risch, Lingeng Lu, Robert S. Brown, Zhanwei Wang, Karen Pawlish, Antoinette M. Stroup, Linda L. Wong, Tamar H. Taddei
Publikováno v:
Cancer Epidemiol Biomarkers Prev
Background: Gut microbial alterations have been linked to chronic liver disease and hepatocellular carcinoma (HCC). The role of the oral microbiome in liver cancer development has not been widely investigated. Methods: Bacterial 16S rRNA sequences we
Autor:
Andriy Zhylko, Marta Klopotowska, Zofia Pilch, Malgorzata Firczuk, Aleksander Slusarczyk, Malgorzata Bajor, Herman Netskar, Dariusz Plewczynski, Karl-Johan Malmberg, Agnieszka Goral, Iwona Baranowska, Agnieszka Graczyk-Jarzynka, Blanka Sharma, Kuba Retecki, Joanna Domagala, Radoslaw Zagozdzon, Mieszko Lachota, Michal Lazniewski, Karolina Soroczynska, Madison N. Temples, Katsiaryna Marhelava, Agnieszka Kraft, Kavita Ramji, Marta Krawczyk, Magdalena Winiarska
Publikováno v:
Cancer Immunology Research. 10:228-244
Oxidative stress, caused by the imbalance between reactive species generation and the dysfunctional capacity of antioxidant defenses, is one of the characteristic features of cancer. Here, we quantified hydrogen peroxide in the tumor microenvironment
Is Hodgkin Lymphoma Associated with Hepatitis B and C Viruses? A Systematic Review and Meta-analysis
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 30:2167-2175
Background: Apart from the Epstein–Barr virus (EBV), the etiology of the hematologic malignancy Hodgkin lymphoma (HL) is not well defined. Hepatitis B virus (HBV) and hepatitis C virus (HCV) are associated with some lymphoproliferative diseases wit
Autor:
Huifen Zhou, Songhui Xu, Cancan Zhang, Qixin Leng, Hao-Wu Jiang, Jiaxi He, Donge Tang, Xin-Yan Geng, De-Xue Fu, Yong Dai, Rui Sun
Publikováno v:
Cancer Research. :OF1-OF15
The histone demethylase KDM6A controls gene expression by the epigenetic regulation of H3K27 methylation and functions in diverse processes, including differentiation, development, and cancer. Here, we investigated the role of KDM6A in prostate cance
Autor:
Sebastian Bauer, Steven Attia, Hans Gelderblom, Peter Reichardt, Gina Z. D'Amato, Michael Heinrich, Julie Meade, Patrick Schöffski, Suzanne George, John Zalcberg, Margaret von Mehren, Jean-Yves Blay, Rodrigo Ruiz-Soto, Ping Chi, César Serrano, Robin L. Jones, Ying Su
Publikováno v:
Clinical Cancer Research, 27(23), 6333-6342. AMER ASSOC CANCER RESEARCH
Scientia
Scientia
Purpose: Most patients with gastrointestinal stromal tumor (GIST) have activating mutations in KIT/PDGFRA and are initially responsive to tyrosine kinase inhibitors (TKI). The acquisition of secondary mutations leads to refractory/relapsed disease. T
Autor:
Yingsong Lin, Toshiyuki Kubo, Kenji Wakai, Noriyuki Akutsu, Masanori Nojima, Youichi Kurozawa, Ryogo Himori, Yasushi Adachi, Akiko Tamakoshi, Mitsuru Mori
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 30:2130-2135
Background: Insulin-like growth factor (IGF)2 is a potent mitogen. To elucidate the relationship between IGF2 and risk of tumorigenesis, we analyzed associations between serum levels of IGF2 and incidence of liver cancer in a prospective case–contr
Autor:
William R. Berry, Samar Masoumi-Moghoddam, Daniel Croagh, Brendan J. Jenkins, Hugh Gao, Joanne Lundy
Publikováno v:
Clinical Cancer Research. 27:5900-5911
Purpose: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis, and current diagnostic tests have suboptimal sensitivity. Incorporating standard cytology with targeted transcriptomic and mutation analysis may impro