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Autor:
Kristan H. Cleveland, Abdullah Shamim, Sherry Liang, Ying Huang, Mengbing Chen, Cyrus Parsa, Bradley T. Andresen, Ayaz Shahid, Robert Orlando
Publikováno v:
Cancer Prev Res (Phila)
Skin cancer is the most common malignancy worldwide and is rapidly rising in incidence, representing a significant public health challenge. The β-blocker, carvedilol, has shown promising effects in preventing skin cancer. However, as a potent β-blo
Autor:
Michael B. Sporn, Di Zhang, Samir J. Ibrahim, Karen T. Liby, Ana S. Leal, Pamela A. Marshall, Carl E. Wagner, Pritika H. Shahani, San Raban, Peter W. Jurutka, Sarah Carapellucci, Jaskaran S. Bhogal
Publikováno v:
Cancer Prevention Research. 12:211-224
Rexinoids, selective ligands for retinoid X receptors (RXR), have shown promise in preventing many types of cancer. However, the limited efficacy and undesirable lipidemic side-effects of the only clinically approved rexinoid, bexarotene, drive the s
Autor:
Tong Zhang, Gayatri Gowrishankar, Aileen Hoehne, Sanjiv S. Gambhir, Oliver D. K. Maddocks, Patrick McCormick, Erik Årstad, Adam J. Shuhendler, Mathias Berndt, Hannah E. Greenwood, Timothy H. Witney, Matthias Glaser, David Y. Lewis, Norman Koglin, Thibault Gendron, Kerstin Sander, Mark F. Lythgoe
Publikováno v:
McCormick, P, Greenwood, H E, Glaser, M, Maddocks, O D K, Gendron, T, Sander, K, Gowrishankar, G, Hoehne, A, Zhang, T, Shuhendler, A J, Lewis, D Y, Berndt, M, Koglin, N, Lythgoe, M, Gambhir, S S, Arstad, E & Witney, T 2019, ' Assessment of tumor redox status through (S)-4-(3-[ 18 F]fluoropropyl)-L-glutamic acid PET imaging of system x c activity ', Cancer Research, vol. 79, no. 4, 79, pp. 853-863 . https://doi.org/10.1158/0008-5472.CAN-18-2634
The cell's endogenous antioxidant system is vital to maintain redox homeostasis. Despite its central role in normal and pathophysiology, no noninvasive tools exist to measure this system in patients. The cystine/glutamate antiporter system xc− main
Autor:
Jamie J. Shah, Francis Y. Lee, Bruce S. Fischer, Hossein Khiabanian, Sharon R. Pine, Joseph R. Bertino, Katherine M. Morgan, Amartya Singh, Jeffrey A. Rosenfeld
Publikováno v:
Molecular Cancer Therapeutics. 16:2759-2769
Notch signaling is aberrantly activated in approximately one third of non–small cell lung cancers (NSCLC). We characterized the interaction between BMS-906024, a clinically relevant Notch gamma secretase inhibitor, and front-line chemotherapy in pr
Autor:
Jill Hallin, Lyudmilla Bazhenova, James G. Christensen, Natalia Baños, Richard C. Chao, Camino Menéndez, Mark M. Awad, Nir Peled, Mizuki Nishino, Peter Olson, V. Tassell, Richard B. Lanman, Geoffrey I. Shapiro, Matthew Randolf Lee, Lars D. Engstrom, Zachary Madaj, Sandip Pravin Patel, Manuel Hidalgo, Ruth Aranda, Carrie R. Graveel, Pasi A. Jänne, David Briere, Elizabeth A. Tovar, Curt J. Essenburg, Harrah Chiang, Pedro P. López-Casas, Darya Chudova
Publikováno v:
Clinical Cancer Research. 23:6661-6672
Purpose: MET exon 14 deletion (METex14 del) mutations represent a novel class of non–small cell lung cancer (NSCLC) driver mutations. We evaluated glesatinib, a spectrum-selective MET inhibitor exhibiting a type II binding mode, in METex14 del–po
Autor:
Christopher J. Morrow, Zhiqiang Li, Joanne Wilson, Sarat Chandarlapaty, Kathryn E. Carlson, Pedram Razavi, Teresa S. Martin, José Baselga, Anne U. Goeppert, Mandy Lawson, Wai Lin Wong, Elisa de Stanchina, Anne Marie Mazzola, Geoffrey L. Greene, John A. Katzenellenbogen, Hazel M. Weir, Aaron Smith, Weiyi Toy, Sharmeen Uddin, Sean W. Fanning
Publikováno v:
Cancer Discovery. 7:277-287
Recent studies have identified somatic ESR1 mutations in patients with metastatic breast cancer and found some of them to promote estrogen-independent activation of the receptor. The degree to which all recurrent mutants can drive estrogen-independen
Autor:
Douglas Grossman, Scott R. Florell, Kenneth M. Boucher, Matthew Honeggar, Tong Liu, Pamela B. Cassidy, Sancy A. Leachman
Publikováno v:
Cancer Prevention Research. 10:36-44
Oxidative stress plays a role in UV-induced melanoma, which may arise from melanocytic nevi. We investigated whether oral administration of the antioxidant N-acetylcysteine (NAC) could protect nevi from oxidative stress in vivo in the setting of acut
Autor:
Michael B. Sporn, Charlotte R. Williams, Martine Cao, Renee Risingsong, Karen T. Liby, Darlene B. Royce
Publikováno v:
Cancer Prevention Research. 9:105-114
LG101506 was originally synthesized to overcome some of the undesirable side effects of rexinoids. We compared the anticarcinogenic action of LG101506 and LG100268 and for the first time showed that both drugs are useful for prevention of lung cancer
Autor:
Peter Mu Hsin Chang, Yu Chen Tsai, Wei-Hsiang Hsu, Alexander T.H. Wu, Tai-shan Cheng, Jin-Mei Lai, Chi Ying F. Huang
Publikováno v:
Cancer Research. 75:A2-32
Cancer stem cell (CSC) theory has drawn much attention, with evidence supporting the contribution of stem cells to tumor initiation, relapse, and therapy resistance. In this study, we focus on screening drugs that target CSCs to improve the current t
Autor:
Félix Bonilla, Cristina Peña, Belén Pérez-Sacristán, F. Granado-Lorencio, Gemma Domínguez, Beatriz Gil-Calderón, Jesús Espinosa Romero, Encarnación Donoso, Coral San Millán, Beatriz Soldevilla, Marta Compte, Paloma Martín
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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[Background]: The acquired resistance to chemotherapy represents the major limitation in the treatment of cancer. New strategies to solve this failure and improve patients' outcomes are necessary. The cancer preventive effect of β-cryptoxanthin has