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Autor:
Levi Sokol, Kim M. Hirshfield, Chandrika Jeyamohan, Srilatha Simhadri, Janice M. Mehnert, Lorna Rodriguez-Rodriguez, Husam Al-Hraishawi, Shridar Ganesan, Sharon R. Pine, Atul Kulkarni, Suzie Chen, Man Lung Teo, Eileen White, Siraj M. Ali
Publikováno v:
Clinical Cancer Research. 23:5631-5638
Purpose: Many patients with BRAFV600E mutant melanoma treated with BRAF inhibitors experience a rapid response, but ultimately develop resistance. Insight into the mechanism of resistance is critical for development of more effective treatment strate
Autor:
Raghu Kalluri, Chanjuan Shi, Valerie M. Weaver, Anna Chytil, Harold L. Moses, Fei Ye, Philip Owens, Sergey V. Novitskiy, Michael W. Pickup, Agnieszka E. Gorska
Publikováno v:
Cancer immunology research, vol 5, iss 9
The survival rate for pancreatic ductal adenocarcinoma (PDAC) remains low. More therapeutic options to treat this disease are needed, for the current standard of care is ineffective. Using an animal model of aggressive PDAC (Kras/p48TGFβRIIKO), we d
Autor:
Douglas Grossman, Scott R. Florell, Kenneth M. Boucher, Matthew Honeggar, Tong Liu, Pamela B. Cassidy, Sancy A. Leachman
Publikováno v:
Cancer Prevention Research. 10:36-44
Oxidative stress plays a role in UV-induced melanoma, which may arise from melanocytic nevi. We investigated whether oral administration of the antioxidant N-acetylcysteine (NAC) could protect nevi from oxidative stress in vivo in the setting of acut
Publikováno v:
Cancer Research. 76:7059-7071
Hepatocellular carcinoma is highly resistant to chemotherapy. Research data supported that cancer stem cells (CSC) may be responsible for the chemoresistance and strategies that suppress CSCs stemness could also inhibit the drug resistance. In this s
Autor:
QT Bui, Keon Wook Kang
Publikováno v:
Cancer Research. 76:P1-05
Epithelial-mesenchymal transition (EMT) is process in which epithelial cells undergo unique morphologic changes characterized by a transition from epithelial cobblestone phenotype to elongated fibroblastic phenotype (mesenchymal phenotype) leading to
Autor:
Randall J. Kimple, Johan Lantto, Zachary S. Morris, David M. Francis, Craig R. Hullett, Eric A. Armstrong, Chunrong Li, Paul M. Harari, Lauryn R. Werner, Adam D. Swick, Michael Kragh, Shyhmin Huang
Publikováno v:
Clinical Cancer Research. 22:633-643
Purpose: Aberrant regulation of the EGF receptor family (EGFR, HER2, HER3, HER4) contributes to tumorigenesis and metastasis in epithelial cancers. Pan-HER represents a novel molecular targeted therapeutic composed of a mixture of six monoclonal anti
Autor:
William J. Irvin, William T. Barry, Eric P. Winer, Sara M. Tolaney, Chau T. Dang, Brandelyn N. Pitcher, Charles M. Perou, Lisa A. Carey, Elaine R. Mardis, Matthew D. Wilkerson, Clifford A. Hudis, Katherine A. Hoadley, Ian E. Krop, Donald A. Berry, Norah Lynn Henry, Joel S. Parker
Publikováno v:
Cancer Research. 75:S3-06
Background: In CALGB 40601, the HER2-Enriched (HER2-E) molecular subtype had significantly higher pathologic complete response (pCR) rates regardless of treatment arm (single HER2-targeting with T+L or T+H, dual targeting with T+H+L) (Carey et al, AS
Autor:
Dorde Komljenovic, Hellmut G. Augustin, André Neumann, Bernd Arnold, Matthias Wieland, Carolin Mogler, Sergij Goerdt, Cyrill Géraud, Jan Philip Bergeest, Peter Schirmacher, Junhao Hu, Karl Rohr, Anja Runge
Publikováno v:
Cancer Research. 74:4157-4169
The limited availability of experimental tumor models that faithfully mimic the progression of human tumors and their response to therapy remains a major bottleneck to the clinical translation and application of novel therapeutic principles. To addre
Autor:
Antonio García de Herreros, Manuel Domine, Silvia Menendez, Montserrat Arumi-Uria, Sandra Zazo, Lara Pijuan, Israel Cañadas, Oriol Arpí, Edurne Arriola, Sergi Mojal, Federico Rojo, Joan Albanell, Marta Salido, Ana Rovira, Álvaro Taus
Publikováno v:
Clinical Cancer Research. 20:938-950
Purpose: Met receptor phosphorylation is associated with poor prognosis in human small cell lung cancer (SCLC). The aim of our work was to investigate the effects of hepatocyte growth factor (HGF)/Met–mediated epithelial-to-mesenchymal transition (
Autor:
I. van Praagh, Catherine Abrial, Frédérique Penault-Llorca, Anne Cayre, Y-J Bignon, Nina Radosevic-Robin, Yannick Bidet, J.P. Jacquin, J-M Nabholtz, F Kwiatkoswki, A-V Bourcier, P. Chollet, N. Chalabi, F Del Piano, M.M. Dauplat, B. Nayl, V. Servent, Pascale Dubray-Longeras, M-A Mouret-Reynier, Nancy Uhrhammer
Publikováno v:
Cancer Research. 73:P1-08
Background: TNBC is a heterogenous group of tumors for some of which the Epithelial Growth Factor Receptor pathway (EGFR) may play an important role. We evaluated the efficacy and toxicity of an anti-EGFR antibody (cetuximab) combined with docetaxel,