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Publikováno v:
Molecular Cancer Research. 13:659-669
KRAS mutations are frequently detected in human colorectal cancer and contribute to de novo apoptosis resistance and ultimately therapeutic failure. To overcome KRAS-mediated apoptosis resistance, the irreversible proteasome inhibitor, carfilzomib, w
Publikováno v:
Cancer research, vol 74, iss 17
Isocitrate dehydrogenase 1 (IDH1) mutations occur in most lower grade glioma and not only drive gliomagenesis but are also associated with longer patient survival and improved response to temozolomide. To investigate the possible causative relationsh
Autor:
Ruiyang Tian, Penelope Miron, Gautam Maulik, Scott J. Rodig, Bose Kochupurakkal, Alexander Miron, Debajit K. Biswas, Shannon T. Bailey, Teresa V. Bowman, Kathleen M. Foley, Yoon Jong Choi, J. Dirk Iglehart, Myles Brown
Publikováno v:
Molecular Cancer Research. 12:408-420
Breast cancers with HER2 overexpression are sensitive to drugs targeting the receptor or its kinase activity. HER2-targeting drugs are initially effective against HER2-positive breast cancer, but resistance inevitably occurs. We previously found that
Autor:
Andrew Weickhardt, Diego D'Ávila Paskulin, Teresa Nguyen, Dara L. Aisner, Robert C. Doebele, Fiona Chionh, Niall C. Tebbutt, Jenny Hardingham, Anh T. Le, Nathan Schulte, Marileila Varella-Garcia, John M. Mariadason, Jerry Haney
Publikováno v:
Molecular Cancer Research. 12:111-118
Activated anaplastic lymphoma kinase (ALK) and ROS1 tyrosine kinases, through gene fusions, have been found in lung adenocarcinomas and are highly sensitive to selective kinase inhibitors. This study aimed at identifying the presence of these rearran
Publikováno v:
Molecular Cancer Research. 11:1624-1635
Protein kinase Cι (PKCι) has oncogenic potential and is an attractive therapeutic target for treatment of lung cancer, particularly those tumors that express elevated PKCι. However, whether PKCι is a viable target in ovarian cancer is unknown, an
Autor:
Jonathan Waxman, Loredana Pellegrino, Jonathan Krell, Victoria Harding, Adam E Frampton, Leandro Castellano, Filipa G. Pinho, Heba Alshaker, D. Pchejetski, Laura Roca-Alonso, Justin Stebbing, Joao Nunes, Jimmy Jacob, Alexander de Giorgio
Publikováno v:
Cancer Research. 73:5936-5948
Sphingosine kinase 1 (SK1) plays an important role in estrogen-dependent breast tumorigenesis, but its regulation is poorly understood. A subset of microRNAs (miRNA, miR) is regulated by estrogen and contributes to cellular proliferation and cancer p
Autor:
Norio Nonomura, Koji Hatano, Mutsumi Tsuchiya, Masashi Nakayama, Souhei Yamaguchi, Akira Nagahara, Kazutoshi Fujita, Yasutomo Nakai, Motohide Uemura, Keisuke Nimura, Yasufumi Kaneda, Kouki Murakami
Publikováno v:
Molecular Cancer Research. 11:1088-1100
Despite an increasing prevalence of patients with docetaxel-refractory prostate cancer, little is known about the tumor biology of the docetaxel-resistant residual tumor cells compared with primary tumor cells. In this study, tumorigenic potential wa
Autor:
Ekkehard Moessner, Pablo Umana, Sylvia Herter, Christian Gerdes, Birgit Bossenmaier, Carola Ries, Michaela Roemmele, Nicolini Valeria G, Hans Joachim Mueller, Thomas Friess, Olivier Freytag, Erwin van Puijenbroek, Sabine Lang
Publikováno v:
Clinical Cancer Research. 19:1126-1138
Purpose: Anti-EGF receptor (EGFR) antibodies and small-molecule tyrosine kinase inhibitors have shown activity in epithelial tumors; however, agents that work by blocking the EGFR growth signal are ineffective when the oncogenic stimulus arises downs
Autor:
Marc Ladanyi, Mark G. Kris, Maria E. Arcila, Gregory J. Riely, Maureen F. Zakowski, Valerie W. Rusch, M. Catherine Pietanza, Camelia S. Sima, Christopher Lau, Paul K. Paik, Jamie E. Chaft
Publikováno v:
Molecular Cancer Therapeutics. 11:485-491
Phosphoinositide-3-kinase catalytic alpha polypeptide (PIK3CA) encodes the p110α subunit of the mitogenic signaling protein phosphoinositide 3-kinase (PI3K). PIK3CA mutations in the helical binding domain and the catalytic subunit of the protein hav
Autor:
Matthew Meyerson, Derek Y. Chiang, Amit Dutt, Ying S. Chao, Sandra Pastorino, William D. Johnson, Robert C. Onofrio, Roel G.W. Verhaak, Jihyun Kwon, Hideo Watanabe, Yuki Yuza, Jeonghee Cho, Santosh Kesari, Andrew D. Cherniack, Xiaoyin Xu, Qing Treitler Zeng, Scott R. VandenBerg
Publikováno v:
Cancer Research. 71:7587-7596
Genomic alterations of the epidermal growth factor receptor (EGFR) gene play a crucial role in pathogenesis of glioblastoma multiforme (GBM). By systematic analysis of GBM genomic data, we have identified and characterized a novel exon 27 deletion mu