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Autor:
Rebecca J. Leeman-Neill, Mark W. Lingen, Joseph S. Bednash, Raja R. Seethala, Shivendra V. Singh, William E. Gooding, Mary C. Panahandeh, Daniel B. Neill, Sonali Joyce, Jennifer R. Grandis, Maria L. Freilino, Sufi M. Thomas
Publikováno v:
Cancer Prevention Research. 4:230-237
Chemoprevention of head and neck squamous cell carcinoma (HNSCC), a disease associated with high mortality rates and frequent occurrence of second primary tumor (SPT), is an important clinical goal. The epidermal growth factor receptor (EGFR)-signal
Publikováno v:
Cancer Research. 71:445-453
Epidermal growth factor receptor (EGFR) monoclonal antibodies (mAb) are used widely to treat metastatic colorectal cancer (mCRC) patients, but it is now clear that patients harboring K-ras mutation are resistant to EGFR mAbs such as cetuximab (Erbitu
Autor:
Kiminobu Arima, Yoshiki Sugimura, Yoichi Iwamoto, Kenichiro Ishii, Hideki Kanda, Yasuhide Hori, Hideaki Kise, Norihito Soga, Kohei Nishikawa
Publikováno v:
Cancer Prevention Research. 4:87-96
In prostate cancer, tumor–stroma interactions play a critical role in the promotion of tumorigenesis, and thus the prevention of those interactions is a promising target to suppress tumor growth. Several studies demonstrated that alpha1-adrenocepto
Autor:
Bharat B. Aggarwal, Sanjit Dey, Sushovan Guha, Zhimin Tong, Parmeswaran Diagaradjane, Juri G. Gelovani, Vivek R. Yadav, Cemile Koca, Jayaraj Ravindran, Bokyung Sung, Sunil Krishnan, Ajaikumar B. Kunnumakkara, Amit Deorukhkar
Publikováno v:
Cancer Research. 70:8695-8705
Pancreatic cancers generally respond poorly to chemotherapy, prompting a need to identify agents that could sensitize tumors to treatment. In this study, we investigated the response of human pancreatic cells to γ-tocotrienol (γ-T3), a novel, unsat
Publikováno v:
Cancer Research. 69:9330-9336
The human epidermal growth factor receptor (HER) family plays an important role in cell survival and proliferation, and is implicated in oncogenesis. Overexpression of HER2 is associated with aggressive disease and poor prognosis. Trastuzumab is a hu
Autor:
Mihai Hajdu, Hiroko Shinoda, Robert G. Maki, Tianhua Guo, Peter Besmer, Cristina R. Antonescu, Bayard D. Clarkson, Narasimhan P. Agaram, Darren R. Veach, Ronald P. DeMatteo, Samuel Singer
Publikováno v:
Clinical Cancer Research. 15:6862-6870
Purpose: Although tyrosine kinase inhibitors have improved survival in advanced gastrointestinal stromal tumor (GIST), complete response is rare and most patients eventually fail the first-line treatment with imatinib. Sunitinib malate is the only ap
Publikováno v:
Cancer Research. 69:7619-7625
Circadian rhythms regulate diverse physiologic processes, including homeostatic functions of steroid hormones and their receptors. Perturbations of these rhythms are associated with pathogenic conditions, such as depression, diabetes, and cancer. And
Autor:
Cristina M. Karp, Eileen White, Kevin Bray, Robert S. DiPaola, Hsin-Yi Chen, Michael May, Shridar Ganesan, Vassiliki Karantza-Wadsworth
Publikováno v:
Molecular Cancer Research. 7:1487-1496
Apoptosis resistance is a hallmark of cancer linked to disease progression and treatment resistance, which has led to the development of anticancer therapeutics that restore apoptotic function. Antiapoptotic Bcl-2 is frequently overexpressed in refra
Autor:
Satoshi Kano, Satoshi Fukuda, Tadasuke Tsukiyama, Shigetsugu Hatakeyama, Naoto Miyajima, Hiroyuki Maeda, Fumihiko Okumura
Publikováno v:
Molecular Cancer Research. 7:1553-1562
The ubiquitin-proteasome system has a crucial role in maintaining and regulating cellular homeostasis including carcinogenesis. UBE2Q2, also designated Ubci, is one of the ubiquitin-conjugating enzymes (E2), and it has been reported that mRNA of UBE2
Autor:
John V. Heymach, Eugene Lifshits, George N. Naumov, Tina Cascone, Daniel G. Tenen, Bruce E. Johnson, Lars A. Akslen, Jeffrey A. Engelman, Monique B. Nilsson, Hua Kang Wu, Oddbjørn Straume, Pasi A. Jänne, Beow Y. Yeap, Balazs Halmos, Xi M. Tang, Alexandra Briggs, Judah Folkman, Lauren Averett Byers, Li Xu, Susumu Kobayashi
Publikováno v:
Clinical Cancer Research. 15:3484-3494
Purpose: The epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) gefitinib and erlotinib benefit some non–small cell lung cancer (NSCLC) patients, but most do not respond (primary resistance) and those who initially respond eve