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Publikováno v:
Cancer Research. 80:694-694
Today, pancreatic cancer (PC) remains a major health problem in the US and soon will be the second most common cause of mortality due to cancer. However, most of the front-line PC chemotherapies cause serious side effects and a majority of patients w
Autor:
Saravanakumar Marimuthu, Imayavaramban Lakshmanan, Sakthivel Muniyan, Maneesh Jain, Surinder K. Batra, Moorthy P. Ponnusamy, Pranita Atri
Publikováno v:
Cancer Research. 80:6072-6072
Pancreatic cancer (PC) is one of the most lethal malignant tumors. Several membrane-bound mucins are overexpressed in PC, including MUC16. The role and molecular mechanism of MUC16 mucin, particularly carboxyl-terminal domain (MUC16-Cter) in metastas
Autor:
Izhak Haviv, Lana Kupershmidt, Evgeny Solomonov, Salomon M. Stemmer, Neta Moskovits, Hadas Reuveni
Publikováno v:
Cancer Research. 79:C45-C45
Background: Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer-related death worldwide, with poor outcome of current treatments. Major contributors to therapeutic resistance in PDAC include Kras mutations, a dense desmoplas
Autor:
Santhi D. Konduri, James L. Weese, Kalkunte S. Srivenugopal, Alisher Holmuhamedov, Jacob Frick, George C. Bobustuc
Publikováno v:
Cancer Research. 75:3493-3493
Background: O6 methylguanine DNA methyltransferase (MGMT) is overexpressed in a majority of cancers, including pancreatic cancer. MGMT has been the focus of significant research for its role in the repair of DNA damage caused by chemotherapeutic agen
Publikováno v:
Clinical Cancer Research. 21:A03-A03
Cancer treatment is complicated when patients develop resistance to standard therapies. Hence, developing strategies to address resistance to chemo therapy and improving therapeutic efficiency is of great importance in treating cancer successfully. R
Publikováno v:
Cancer Research. 74:4702-4702
Caveolin-1 (Cav-1) is a 21kDa protein found in 50-100nm omega-shaped invaginations of the plasma membrane known as caveolae. It has been implicated in the processes of oncogenic cell transformation, tumorigenesis and metastasis. Cav-1 is upregulated
Publikováno v:
Cancer Research. 72:5623-5623
Pancreatic cancer is arguably one of the most challenging human malignancies, with the five year survival rate below 5%. Pancreatic cancer is often found in advanced stages, and is unresponsive to conventional cancer therapy. Thus, the need to develo
Publikováno v:
Molecular Cancer Therapeutics. 10:B145-B145
Metastasis, or the spread of disseminated tumor cells to and colonization of distal sites, is a major cause of cancer mortality. The Hedgehog (Hh) signaling pathway is normally involved in embryogenesis; however recent evidence suggests a role for th
Autor:
Michelle Lockley, Takashi K. Kishomoto, Jay Duffner, Martijn P. Lolkema, He Zhou, David A. Tuveson
Publikováno v:
Cancer Research. 70:LB-43
Introduction: Heparan sulphate proteoglycans (HSPGs) play a central role in tumor progression and metastasis by presenting and modulating growth factors, cytokines, and other soluble factors. A novel heparin sulphate mimetic (M402), engineered from h