Zobrazeno 81 - 90
of 518
pro vyhledávání: ''
Autor:
Elizabeth Garrett-Mayer, Julie Gottlieb Fisher, Timothy L. Cannon, Pam K. Mangat, Ricardo H. Alvarez, Samiha Islam, Susan Halabi, Andrew L. Rygiel, Kaitlyn R. Antonelli, Theodore Pollock, Suanna S. Bruinooge, Richard L. Schilsky, Jared Addison Cotta, Pamela A. Crilley, Tareq Al Baghdadi
Publikováno v:
Cancer Research. 79:CT135-CT135
Background: The TAPUR Study is a phase II multi-basket study that evaluates the anti-tumor activity of commercially available targeted agents in pts with advanced cancers with genomic alterations known to be drug targets. Results in two cohorts of BC
Publikováno v:
Cancer Research. 73:P5-09
The 88 kDa glycoprotein GP88 (Progranulin, PCDGF, acrogranin) is the largest member of the granulin/epithelin family of growth modulators. GP88 was originally characterized in our laboratory through a biological screen to identify drivers of tumorige
Autor:
I. van Praagh, Catherine Abrial, Frédérique Penault-Llorca, Anne Cayre, Y-J Bignon, Nina Radosevic-Robin, Yannick Bidet, J.P. Jacquin, J-M Nabholtz, F Kwiatkoswki, A-V Bourcier, P. Chollet, N. Chalabi, F Del Piano, M.M. Dauplat, B. Nayl, V. Servent, Pascale Dubray-Longeras, M-A Mouret-Reynier, Nancy Uhrhammer
Publikováno v:
Cancer Research. 73:P1-08
Background: TNBC is a heterogenous group of tumors for some of which the Epithelial Growth Factor Receptor pathway (EGFR) may play an important role. We evaluated the efficacy and toxicity of an anti-EGFR antibody (cetuximab) combined with docetaxel,
Autor:
P-L Kellokumpu-Lehtinen, Petri Bono, M. Leinonen, Vesa Kataja, H Joensuu, Ralph M. Wirtz, Sirkku Jyrkkiö, Jorma Isola, Marcus Schmidt, Taina Turpeenniemi-Hujanen, Sebastian Eidt
Publikováno v:
Cancer Research. 73:P1-08
Background: Tumor immune cell infiltrates influence prognosis of node negative breast cancer (BC), and intratumoral B-cells and T-cells are of importance for achieving response to chemotherapy in triple negative BC. The role of tumor infiltrating mac
Autor:
F Andre, JL Merlin, Maria Rios, Jennifer Wong, M. Campone, Delphine Loussouarn, Isabelle Treilleux, Véronique Diéras, Maëva Lion, M. Jimenez, J. Bonneterre, Thomas Bachelot, Agnès Leroux
Publikováno v:
Cancer Research. 73:P1-08
Background: PI3-kinase (PI3K) and MAP kinase (MAPK) are the main signaling pathways implicated in molecular oncogenesis. In breast cancer, inhibition of these signaling pathways has been largely envisaged by means of targeted therapy. Unicancer RADHE
Publikováno v:
Cancer Research. 73:P5-09
Introduction: BP1 is a member of the homeobox gene family of transcription factors. Our recent studies have shown that BP1 may play a role in breast cancer cell survival, aggressiveness and metastasis. BP1 protein (pBP1) is expressed in 80% of invasi
Autor:
Thahir Farzan, Kimberly R. Kalli, Paul Haluska, Marc A. Becker, S. John Weroha, Tai W. Wong, Sean C. Harrington, James Krempski, Xiaonan Hou
Publikováno v:
Molecular Cancer Therapeutics. 12:2909-2916
Ovarian cancer mortality ranks highest among all gynecologic cancers with growth factor pathways playing an integral role in tumorigenesis, metastatic dissemination, and therapeutic resistance. The HER and VEGF receptor (VEGFR) are both overexpressed
Autor:
Yasumasa Okazaki, Shan Hwu Chew, Hirotaka Nagai, Shinya Toyokuni, Hiroyuki Yasui, Nobuaki Misawa
Publikováno v:
Cancer Prevention Research. 6:1222-1230
Asbestos was used worldwide in huge quantities in the past century. However, because of the unexpected carcinogenicity to mesothelial cells with an extremely long incubation period, many countries face this long-lasting social problem. Mesothelioma i
Autor:
Heather Beckwith, Douglas Yee
Publikováno v:
Cancer Research. 75:P4-06
Targeting endocrine resistant breast cancer cells has been successfully accomplished by the use of mTORC1 inhibitors in combination with either aromatase inhibitors or tamoxifen. While there was preclinical data suggesting that targeting of the type
Autor:
Larry G. Thaete, Viqar Syed, Thomas P. Conrads, Guisong Wang, Pang-ning Teng, Gustavo C. Rodriguez, Brian L. Hood, Chad A. Hamilton, Jane Turbov, Huyen Nguyen, Leyla Kavandi, Laura R. Lee, George L. Maxwell
Publikováno v:
Cancer Prevention Research. 6:731-743
Human studies suggest that progesterone and calcitriol may prove beneficial in preventing or inhibiting oncogenesis, but the underlying mechanism is not fully understood. The current study investigates the effects of progesterone, calcitriol, and the